HEART DIS & COPD: EXERCISE METAB & OXYGEN DELIVERY IN HEALTH & DISEASE

心迪

• 批准号: 6349332
• 负责人: ELIZABETH A NOYSZEWSKI
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6349332
• 关键词: alternative medicine; bioimaging /biomedical imaging; biomedical resource; liver; magnetic resonance imaging; medical rehabilitation related tag; nervous system; pain; rehabilitation; skeletal system; technology /technique

Acupuncture is a significant component of traditional Chinese medicine. It has been practiced in China for thousands of years as part of the treatment for diverse medical conditions. It is gradually becoming accepted in Western countries as a method of pain relief and in the treatment of other diseases. In addition, there is more and more research into the physiological effects of acupuncture on human bodies. This study is an exploration of the physical effects of acupuncture on humans. Using magnetic resonance imaging and spectroscopic techniques (MRI & MRS), we will examine signal changes, if any, in cerebral activity and body metabolism in response to acupuncture stimulation. We hypothesize that acupuncture treatment will modify blood flow patterns and metabolic rates. We have been testing the applicability of blood flow quantification techniques to this study, particularly insofar as they enable us to identify the functional changes induced by acupuncture in the brain, skeletal muscle and visceral organs. Using fMRI, we will compare the brain activation pattern before, during, and after acupuncture treatment. We will also generate data from control group of subjects not treated with acupuncture. We did two case studies with flow quantification method. One case was to observe the effects of acupuncture at acupoints St36 on leg blood flow quantified with 2D-flash flow sensitive sequence. The other one was, using the similar sequence, to observe how acupunture would influence the flow of portal vein and kidney arteries. There are indication of flow change induced by acupuncture. However, more subjects need to be studied for conclusive results.

针灸是中医的重要组成部分 药品。 它在中国已经实践了数千年 不同医疗状况治疗的一部分。 是逐渐 作为一种缓解疼痛的方法在西方国家被接受 在其他疾病的治疗中。 此外，还有更多和 更多针灸对人体生理效应的研究 尸体。 这项研究是对物理效应的探索 对人体进行针灸。 使用磁共振成像和 光谱技术（MRI 和 MRS），我们将检查信号变化， 如果有的话，大脑活动和身体新陈代谢的反应 针灸刺激。 我们推测针灸治疗 会改变血流模式和代谢率。 我们一直在测试血流的适用性 本研究的量化技术，特别是它们 使我们能够识别针灸引起的功能变化 大脑、骨骼肌和内脏器官。 使用功能磁共振成像，我们将 比较之前、期间和之后的大脑激活模式 针灸治疗。 我们还将生成对照组的数据 未接受针灸治疗的受试者。 我们用流量量化方法做了两个案例研究。 一 案例是观察针刺St36穴位对 使用 2D 闪流敏感序列对腿部血流量进行量化。 这 另一项是使用类似的顺序，观察针灸如何 会影响门静脉和肾动脉的血流。 那里 是针灸引起的血流变化的指示。 然而，更多 需要对主题进行研究以获得结论性结果。