EXERCISE METABOLISM & OXYGEN DELIVERY IN CHRONIC RENAL FAILURE
运动代谢
基本信息
- 批准号:6121069
- 负责人:
- 金额:$ 1.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-30 至 1999-09-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Erythropoietin (EPO) has proven to be effective in the treatment
of anemia caused by chronic renal failure (CRF). Though such
treatment does improve the quality of life, peak oxygen uptake after
EPO therapy does not improve as much as one would predict given the
increase in hemoglobin concentration. We predicted that uremic
myopathy provokes a cytosolic dysfunction without altering
mitochondrial oxidative capacity. To test this hypothesis, we tested
six CRF patients and six matched sedentary normals here and at the
University of Barcelona. We found no mitochondrial differences
between the two groups. However, the oxygen gradients from capillary
to muscle cell were higher in the CRF group, while peak oxygen uptake
was reduced. Moreover, the transcapillary gradient and oxygen uptake
levels for the CRF group breathing 100% oxygen were equivalent to the
normals group at 21% oxygen (room air). The findings suggest that the
muscle weakness observed in CRF patients is due to an impaired oxygen
delivery system, probably as a result of degeneration in the capillary
network. We are currently performing morphometry studies on biopsied
samples from these subjects to corroborate these findings.
促红细胞生成素(EPO)已被证明是有效的治疗
慢性肾功能衰竭(CRF)的病因是什么? 尽管此类
治疗确实改善了生活质量,
EPO治疗并没有像人们预测的那样改善,
血红蛋白浓度增加。 我们预测尿毒症
肌病引起胞质功能障碍,
线粒体氧化能力 为了验证这一假设,我们测试了
六名CRF患者和六名相匹配的久坐不动的正常人,
巴塞罗那大学。 我们没有发现线粒体差异
两组之间的差异。 然而,来自毛细血管的氧梯度
CRF组肌细胞氧摄取峰值高于对照组,
减少了。 此外,跨毛细血管梯度和氧摄取
CRF组呼吸100%氧气的水平相当于
正常组21%氧气(室内空气)。 研究结果表明,
在CRF患者中观察到的肌无力是由于氧气受损
输送系统,可能是由于毛细血管变性
网络 我们目前正在对活检组织进行形态测量学研究。
来证实这些发现
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ELIZABETH A NOYSZEWSKI其他文献
ELIZABETH A NOYSZEWSKI的其他文献
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{{ truncateString('ELIZABETH A NOYSZEWSKI', 18)}}的其他基金
HEART DIS & COPD: EXERCISE METAB & OXYGEN DELIVERY IN HEALTH & DISEASE
心迪
- 批准号:
6657666 - 财政年份:2002
- 资助金额:
$ 1.35万 - 项目类别:
HEART DIS & COPD: EXERCISE METAB & OXYGEN DELIVERY IN HEALTH & DISEASE
心迪
- 批准号:
6495475 - 财政年份:2001
- 资助金额:
$ 1.35万 - 项目类别:
HEART DIS & COPD: EXERCISE METAB & OXYGEN DELIVERY IN HEALTH & DISEASE
心迪
- 批准号:
6349332 - 财政年份:2000
- 资助金额:
$ 1.35万 - 项目类别:
EXERCISE METABOLISM & OXYGEN DELIVERY IN CHRONIC RENAL FAILURE
运动代谢
- 批准号:
6252182 - 财政年份:1997
- 资助金额:
$ 1.35万 - 项目类别:
CLINICAL APPLICATION OF DEOXYMYOGLOBIN TECHNIQUE: PERIPHERAL VASCULAR DIS OR CFS
脱氧肌红蛋白技术的临床应用:外周血管 DIS 或 CFS
- 批准号:
5224011 - 财政年份:
- 资助金额:
$ 1.35万 - 项目类别:
MAGNETIC RESONANCE SPECTROSCOPY OF NORMAL BREAST TISSUE AT 4 TESLA
4 特斯拉下正常乳腺组织的磁共振波谱
- 批准号:
5224028 - 财政年份:
- 资助金额:
$ 1.35万 - 项目类别:
THEORETICAL ANALYSIS OF OXYGEN DELIVERY TO TISSUE: STROKE OR VASCULAR DIS
组织供氧的理论分析:中风或血管障碍
- 批准号:
5224015 - 财政年份:
- 资助金额:
$ 1.35万 - 项目类别:
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