METABOLIC BASIS OF CONJUGATED DIENES TOXICITY

共轭二烯毒性的代谢基础

• 批准号: 6309151
• 负责人: Adnan A. Elfarra
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309151
• 关键词: Mammalia; biological products; biomedical resource; drug adverse effect; environmental toxicology; hematology; neoplasm /cancer; nuclear magnetic resonance spectroscopy; respiratory system

The broad objectives of the proposed research are to elucidate pathways of metabolic activation and detoxification of conjugated dienes, and to characterize the biochemical and chemical mechanisms by which conjugated dienes exert toxicological effects. Current research involves characterization by DNA and hemoglobin adducts and confirmation of the synthesis of chemical compounds. This information is needed in order to understand the biochemical basis of target-organ selectivity and species variability. (NIH ES 06841).

拟议研究的广泛目标是阐明 代谢激活和共轭排毒的途径 Dienes，并通过表征生化和化学机制 结合二烯发挥毒理作用。 当前的研究 涉及DNA和血红蛋白加合物的表征以及 确认化合物的合成。 此信息 为了了解目标器官的生化基础需要 选择性和物种变异性。 （NIH ES 06841）。