COMPLEXES INVOLVED IN RECEPTOR MEDIATED SIGNALING

t3W I 膜受体参与细菌趋化作用。 它们具有 N 端胞质外传感域，通过以下方式连接 螺旋连接至细胞质中的 C 末端信号传导结构域。 受体 信号传导涉及蛋白激酶 CheA 的调节。 激酶 激活需要形成 6-8 的高阶复合物 每个 CheA 的信号传导域。 通过 EK，这些活性复合物似乎是 圆柱形束。 STEM 研究的启动是为了试图确定 组分的化学计量。

In bacterial chemotaxis, t3W I membrane receptors are involved. These have N-terminal extracytoplasmic sensing domains connected by helices to C-terminal signaling domains in the cytoplasm. Receptor signaling involves regulation of a protein kinase, CheA. Kinase activation requires the formation of a higher order complex of 6-8 signaling domains per CheA. By EK these active complexes appear to be cylindrical bundles. STEM studies were initiated to try to deternime the stoichionietry of the components.