COMPLEXES INVOLVED IN RECEPTOR MEDIATED SIGNALING

参与受体介导信号转导的复合物

• 批准号: 6444678
• 负责人: Yi Liu
• 金额: $ 29.31万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444678
• 关键词: bacteria; biological products; biomedical resource; genetics; minerals; taste

In bacterial chemotaxis, t3W I membrane receptors are involved. These have N-terminal extracytoplasmic sensing domains connected by helices to C-terminal signaling domains in the cytoplasm. Receptor signaling involves regulation of a protein kinase, CheA. Kinase activation requires the formation of a higher order complex of 6-8 signaling domains per CheA. By EK these active complexes appear to be cylindrical bundles. STEM studies were initiated to try to deternime the stoichionietry of the components.

在细菌趋化性中，涉及t3 WI膜受体。 这些具有N-末端胞质外传感结构域， 螺旋到细胞质中的C-末端信号结构域。 受体 信号传导涉及蛋白激酶CheA的调节。 激酶 活化需要形成6-8的更高阶络合物 每个CheA的信号结构域。 通过EK，这些活性络合物似乎是 圆柱束 STEM研究开始试图确定 组分的化学计量比。