SYNTHESIS & ENZYME STUDIES USING CREATINE ANALOGS

合成

• 批准号: 6308813
• 负责人: GEORGE L KENYON
• 金额: $ 0.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308813
• 关键词: biomedical resource; spectrometry; structural biology

We have focused on the synthesis of creatine analogs as well as kinetic studies to probe the active site of the enzyme creatine kinase. With the designed substrate analogs, we will be able to see which functional groups of the substrate are most vital to the enzyme activity and alsoto see what additional groups can be permitted without loss of biological activity.

我们已经专注于肌酸类似物的合成以及