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SYNTHESIS & ENZYME STUDIES USING CREATINE ANALOGS

SYNTHESIS & ENZYME STUDIES USING CREATINE ANALOGS
合成
批准号：
6308813
负责人：
GEORGE L KENYON
金额：
$0.99万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-03-01 至 2002-02-28
来源：
https://reporter.nih.gov/project-details/6308813
关键词：
biomedical resource spectrometry structural biology

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中文摘要
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英文摘要
We have focused on the synthesis of creatine analogs as well as kinetic studies to probe the active site of the enzyme creatine kinase. With the designed substrate analogs, we will be able to see which functional groups of the substrate are most vital to the enzyme activity and alsoto see what additional groups can be permitted without loss of biological activity.
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CATALYTIC MECHANISM OF MANDELATE RACEMASE & OTHER MANDELATE ENZYMES
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STRUCTURE BASED DRUG DESIGN FOR TREATMENT OF PARASITIC & VIRAL DISEASES
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