COHORT STUDY OF DIETARY SUPPLEMENTS AND CANCER RISK

膳食补充剂与癌症风险的队列研究

• 批准号: 6434662
• 负责人: Emily WHITE
• 金额: $ 12.54万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-23 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6434662
• 关键词: ascorbate; breast neoplasms; cancer registry /resource; cancer risk; clinical research; colon neoplasms; dietary calcium; dietary supplements; gene environment interaction; human genetic material tag; human middle age (35-64); human old age (65+); human subject; lung neoplasms; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; prostate neoplasms; questionnaires; tocopherols; vitamins

Vitamin and mineral supplements are among the most commonly used drugs in the U.S. Neither chemoprevention trials nor observational studies have established the benefits or risks of supplemental use. The aim of this proposal is to investigate the association of intake of supplemental vitamin C, vitamin E, calcium and multivitamins with total cancer incidence. To meet this aim, a cohort will be recruited within the 13 counties of western Washington State, and followed for a mean of 2 1/4 years. A mailing will be sent to 300,000 men and women age 50-74 using names obtained from a commercial mailing list, which will include a recruitment letter targeting supplemental users and a questionnaire. The recruitment procedures have been tested, and should yield 35,000 male respondents and 40,000 female respondents with 75% of respondents having used at least one dietary supplement in the prior 10 years. The questionnaire solicits detailed information on supplement use over the last 10 years, and information on covariates that may be associated with supplement use and with future risk of cancer (e.g., medical history, cancer risk factors, cancer screening, reasons for supplement use). The questionnaire also incorporates a food frequency questionnaire, with additional items on supplemented foods. A second mailing to respondents 2-4 months later will supply a tape measure for anthropometric measures and brushes for collection of DNA from cheek cells. Studies to quantify the relative validity of our primary exposure measures will be conducted. Endpoint information will be efficiently and accurately collected by linking participant identifiers to the system Washington SEER cancer registry and the Washington State death tapes. Out-migration from the attachment areas of these files will be monitored by linkage to the National Change of Address tape. Longer term follow-up of this cohort will allow the investigation of the association of supplements with specific cancers (lung, prostate, breast and large bowel) and with total mortality, and will allow investigation of gene-supplement interactions. If supplements are harmful or of no use, this information would be important for the large number of Americans taking supplements. If a beneficial effect is found, it could be translated into highly cost effective cancer control measures.

维生素和矿物质补充剂是美国最常用的药物之一。化学预防试验和观察性研究都尚未确定补充剂使用的益处或风险。该提案的目的是调查补充维生素 C、维生素 E、钙和多种维生素的摄入量与癌症总发病率的关系。为了实现这一目标，将在华盛顿州西部 13 个县招募一批队列，并进行平均 2 1/4 年的随访。将使用从商业邮件列表中获得的姓名向 300,000 名 50-74 岁的男性和女性发送一封邮件，其中将包括一封针对补充用户的招募信和一份调查问卷。招募程序已经过测试，应有 35,000 名男性受访者和 40,000 名女性受访者，其中 75% 的受访者在过去 10 年内至少使用过一种膳食补充剂。该调查问卷征求过去 10 年补充剂使用情况的详细信息，以及可能与补充剂使用和未来癌症风险相关的协变量信息（例如病史、癌症风险因素、癌症筛查、补充剂使用原因）。该调查问卷还包含食物频率调查问卷，以及有关补充食品的附加项目。 2-4 个月后，第二次向受访者邮寄将提供用于人体测量的卷尺和用于从面颊细胞收集 DNA 的刷子。将进行研究来量化我们主要暴露措施的相对有效性。通过将参与者标识符链接到华盛顿 SEER 癌症登记系统和华盛顿州死亡磁带，可以有效、准确地收集端点信息。这些文件附件区域的向外迁移将通过与国家地址变更磁带的链接进行监控。该队列的长期随访将允许研究补充剂与特定癌症（肺癌、前列腺癌、乳腺癌和大肠癌）以及总死亡率的关联，并将允许研究基因补充剂相互作用。如果补充剂有害或无用，那么此信息对于大量服用补充剂的美国人来说非常重要。如果发现有益效果，则可以转化为极具成本效益的癌症控制措施。