A novel genotype of hepatitis B virus in Indigenous Australians with an aggressive phenotype and poor vaccine efficacy: implications for clinical care and public health policy

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Hepatitis B virus infection (HBV) is common in Indigenous Australian people and can cause liver damage and liver cancer. The HBV strain in NT Indigenous people is an unusual one which appears more aggressive than common strains and is a poor match for the current HBV vaccine. We will determine the geographical extent and natural history of this strain and explore possible solutions in order to refine clinical and public health approaches to this common but poorly understood chronic disease.