The first validation of personalised dosimetry for molecular radiotherapy using 3D printed organs - Invited resubmission.

有了这笔赠款，我们将开发第一个系统，用于准确验证接受癌症治疗的患者的器官剂量估计，该系统使用针对肿瘤的放射性材料，称为分子放射治疗(MRT)。目前，在测试对患者体内肿瘤和关键器官的辐射剂量测量的准确性时，使用大小不一的简单充满水的圆柱体或球体来表示患者的器官。这些圆柱体被用作校准，将SPECT伽马相机系统中检测到的伽马射线数量转换为患者器官内的活动。我们目前的研究表明，这种校准方法实际上可以导致器官剂量估计的系统误差高达40%，从而阻止个性化患者治疗的优化。因此，相当数量的患者目前没有接受最佳治疗。通过使用基于患者器官CT扫描的逼真3D打印模型，我们可以准确地确定当前商业系统测量单个患者器官的剂量的情况。这为这些系统提供了第一个严格的验证，如果这些系统要用于所有患者的治疗，这是一个必要的要求。我们的3D打印模型还将基于真实器官几何形状，为用于测量MRT剂量的SPECT扫描仪系统提供更准确的活动校准。准确的MRT剂量信息现在被认为在整个欧洲国家非常重要。立法现在建议对每个接受分子放射治疗的患者进行准确的剂量测定。我们的研究将为评估临床科室使用的剂量学系统提供一个新的金标准。这将突出当前系统中的任何弱点，并与我们新的现实校准系数测量相结合，将使所有SPECT相机系统和MRT疗法的剂量测量精度得到提高。通过建立当前剂量测量系统的精度，我们将能够提供一条途径，基于我们最近的研究和基于我们3D打印模型的未来开发的技术，改进当前的商业系统。我们目前正在与一家领先的核医学工作站软件提供商合作，他们正在支持我们验证他们的系统的工作。一个经过严格验证的商业系统有可能显著改善欧洲每年进行的约201，00例MRT治疗的结果。

With this grant we will develop the first system for accurately validating organ dose estimates for patients receiving cancer therapy using radioactive materials which target their tumours, known as Molecular Radiotherapy (MRT). Currently simple water filled cylinders or spheres of varying sizes are used to represent patient organs when testing the accuracy of measurements of radiation dose delivered to tumours and critical organs in a patients body. These cylinders are used as a calibration to convert the number of gamma rays detected in a SPECT gamma-camera system to an activity inside a patient's organ. Our current research has shown that this calibration method can actually result in organ dose estimates with systematic errors of up to 40%, preventing individualised patient treatments from being optimised. Consequently a significant number of patients do not currently receive the optimal therapy.By using realistic 3D printed models based on CT scans of patient organs we can accurately determine how well current commercial systems measure the dose to individual patient organs. This provides the first rigorous validation of these systems, a necessary requirement if the systems are to be used for all patient therapies. Our 3D printed models will also provide a much more accurate activity calibration, based on real organ geometries, for the SPECT scanner systems used to measure dose for MRT.Accurate MRT dose information is now considered very important in countries across Europe. Legislation now recommends accurate dosimetry for every patient receiving Molecular radiotherapy treatment. Our research will provide a new gold standard for assessing dosimetry systems used in clinical departments. This will highlight any weaknesses in current systems and in combination with our new realistic calibration factor measurements will allow the accuracy of dose measurements to be improved for all SPECT camera systems and MRT therapies.By establishing the accuracy of current dosimetry systems we will be able to provide a pathway to improve current commercial systems based on techniques from our recent research and future developments based on our 3D printed models. We are currently working with a leading provider of nuclear medicine workstation software who are supporting our work to validate their system. A rigorously validated commercial system has the potential to provide a significant improvement in the outcome of an estimated 201,00 MRT therapies performed annually in Europe.