Women's knee motion patterns in functional activities

女性功能活动中膝关节的运动模式

• 批准号: 6346717
• 负责人: BING YU
• 金额: $ 11.98万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6346717
• 关键词: biomechanics; clinical research; disease /disorder proneness /risk; estrogens; female; gait; gender difference; human subject; knee; lifestyle; osteoarthritis; women's health

Women have a greater prevalence rate of knee osteoarthritis than men do. Although some risk factors for knee osteoarthritis in women have been qualitatively identified, limited studies exist regarding the quantitative nature of risk factors for knee osteoarthritis. Particularly limited are the studies addressing the differences in lower extremity motion patterns between women and men in daily functional activities, and the effects of the motion patterns on the risk of knee osteoarthritis in women. Our recent studies suggest that women may have different knee motion patterns from men, and that stair climbing may be a more sensitive evaluation procedure for knee disorders. The objective of our long-term research project is to identify modifiable motion related risk factors for knee osteoarthritis in women and develop corresponding prevention strategies. The purpose of the proposed study is to obtain basic understanding of the differences in knee motion patterns between women and men in selected daily functional activities such as level walking and stair climbing, and the effects of estrogen level on women's knee motion patterns in these activities. The knee flexion angle, valgus-varus angle, internal rotation angle, flexion-extension moment, and valgus-varus moment will be used as knee motion measures. Knee static alignment angle will also be measured. The specific aims of this study are: Specific Aim l: To compare the knee motion patterns between women and men during the stance phases of level walking and stair climbing including ascending and descending. Specific Aim 2: To determine the effect of women's estrogen level on the women's knee motion patterns in level walking and stair climbing. Specific Aim 3: To compare static knee alignment angle with weight bearing between women and men. Specific Aim 4: To determine the relationship between static knee alignment angle with weight bearing and maximum knee valgus or varus angle in level walking and stair climbing.

女性膝关节骨关节炎的患病率高于男性。虽然已经定性确定了女性膝关节骨关节炎的一些风险因素，但关于膝关节骨关节炎风险因素的定量性质的研究有限。特别是有限的研究是解决女性和男性在日常功能活动中下肢运动模式的差异，以及运动模式对膝关节疾病风险的影响。 女性的骨关节炎我们最近的研究表明，女性可能有不同的膝关节运动模式从男性，爬楼梯可能是一个更敏感的评估程序膝关节疾病。我们的长期研究项目的目标是确定可改变的运动相关的风险因素，为膝关节骨关节炎的妇女和制定相应的预防策略。拟议研究的目的是获得对差异的基本了解 在选择的日常功能活动，如水平行走和爬楼梯，女性和男性之间的膝关节运动模式，以及雌激素水平对女性在这些活动中的膝关节运动模式的影响。膝关节屈曲角、外翻-内翻角、内旋角、屈曲-伸展力矩和外翻-内翻力矩将用作膝关节运动测量。还将测量膝关节静态对线角。 这项研究的具体目标是： 具体目标1：比较男女在平地行走和爬楼梯站立阶段（包括上升和下降）的膝关节运动模式。 具体目标2：确定女性雌激素水平对女性在平地行走和爬楼梯时膝关节运动模式的影响。 具体目标3：比较女性和男性在负重时的静态膝关节对线角。 具体目标4：目的：探讨负重膝关节静态对线角与平地行走和爬楼梯时膝关节最大外翻或内翻角的关系。