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INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES

INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
有缺陷的流感病毒的干扰
批准号：
6373681
负责人：
DEBI P. NAYAK
金额：
$19.69万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-30 至 2003-08-31
来源：
https://reporter.nih.gov/project-details/6373681
关键词：
Orthomyxoviridae RNA directed DNA polymerase enzyme complex immunoprecipitation influenza vaccines interfering virus nucleocapsid protein structure function site directed mutagenesis vaccine development

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中文摘要
翻译
描述：用于流感病毒复制的3病毒聚合酶（3P）
英文摘要
DESCRIPTION: For replication of influenza virus, 3 viral polymerase (3P) proteins (PA, PB1 and PB2) are necessary. The long term goal of this proposal is to find ways to interfere with the polymerase activity for a safe live virus vaccine. The aims of this proposal are: 1. how the polymerase complex is formed, 2. what are the functions of each polymerase protein, 3. what are the domains and sequence requirements for these functions, 4. what are the functions of nucleocapsid protein (NP) in modulating the polymerase activity, and 5. what are the requirements of type (A, B, and C) specificity for viral polymerases?
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会议论文
Development of live attenuated influenza virus vaccine
Development of live attenuated influenza virus vaccine
INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
INTERFERENCE BY DEFECTIVE INFLUENZA VIRUSES
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