CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE

免疫衰老中的细胞周期和凋亡基因

• 批准号: 6341521
• 负责人: Argyrios N Theofilopoulos
• 金额: $ 30.21万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6341521
• 关键词: RNase protection assay; T lymphocyte; aging; apoptosis; cell cycle; cyclins; enzyme inhibitors; genetically modified animals; immunologic memory; immunosenescence; laboratory mouse; protein kinase; tissue /cell culture

DESCRIPTION (Adapted from the Investigator's abstract): This application is based on the hypothesis that immunologic senescence of T-cells is the results of two concurrent and interrelated events. The T-cell repertoire is reshaped by an expanded memory lymphocyte pool. The memory T-cells themselves reach a refractory (anergic) state manifested by further resistance to further activation, cell cycle entry and apoptosis. The first effect is attributed to the dilution of naive cells by the accumulated memory phenotype cells that leads to overall repertoire constrictions. The second effect is attributed to a generational clock that records an allocated number of activations and cell divisions by memory T-cells before promoting replicative senescence primarily by the buildup of cyclin kinase inhibitors. These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence.

描述（根据调查员的摘要改编）：此应用程序是 基于以下假设：T细胞的免疫学衰老是 两个并发和相互关联的事件的结果。 T细胞曲目是 由扩展的记忆淋巴细胞池重塑。 内存T细胞 自己达到了进一步表现出的难治性（厌食）状态 抵抗进一步激活，细胞周期进入和凋亡。 第一个 效果归因于蓄积细胞稀释 记忆表型细胞，导致整体曲目收缩。 这 第二个效果归因于记录一个世代时钟 通过内存t细胞分配的激活和单元格部门之前 主要通过细胞周期蛋白激酶的积累来促进复制衰老 抑制剂。 这些对老化T细胞细胞周期和凋亡的研究将 有助于定义与 免疫衰老。