EarLab: A Virtual Hearing Laboratory

EarLab：虚拟听力实验室

• 批准号: 6411896
• 负责人: David C. Mountain
• 金额: $ 44.53万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-24 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6411896
• 关键词: acoustic nerve; auditory stimulus; auditory threshold; automated data processing; behavioral /social science research tag; biomedical facility; biophysics; chickens; cochlea; disease /disorder model; electrophysiology; gerbil /jird; hearing; hearing disorders; heterodyning; informatics; laboratory mouse; microelectrodes; model design /development; neurobiology; neurons; neurosciences; psychophysics; psychophysiology; sound perception; video microscopy

DESCRIPTION (provided by applicant): The long-range goal of the EarLab project is to create realistic, web-based models capable of predicting human auditory responses to a wide range of acoustic stimuli or environmental insults. Applications range from predicting how acoustic over-stimulation leads to hearing impairment to explaining how humans are able to function in complex acoustic environments. To achieve our goal we will synthesize and integrate existing information on mammalian hearing and create tools that will facilitate effective interaction between investigators from different research disciplines. The models will improve our ability to take the knowledge obtained from animal models and apply it to humans. In the process of constructing and integrating the EarLab models and tools, data gaps will be identified that will need to be filled by future animal and/or human studies. The neuroscience objectives are to: 1) develop an integrated model of cochlear function, 2) develop a model of noise-induced hearing loss, and 3) develop integrated models of sound-source localization. The informatics goals are: 1) to create the computational infrastructure for a web-based auditory modeling environment, 2) to create an intelligent virtual laboratory that will allow rapid reconfiguration of simulations and interchange of model modules, as well as reference information to aid simulation design, and 3) to develop a user interface for model configuration and data visualization.

描述（由申请人提供）：EarLab项目的长期目标 是创建现实的，基于网络的模型，能够预测人类的听觉 对大范围的声音刺激或环境损伤的反应。 应用范围从预测声学过度刺激如何导致 听力障碍解释人类如何能够在复杂的 声学环境为了实现我们的目标，我们将综合和整合 关于哺乳动物听力的现有信息，并创建工具， 来自不同研究的研究者之间的有效互动 学科这些模型将提高我们利用所获得的知识的能力 并将其应用于人类。在建设过程中， 通过整合EarLab模型和工具，将确定数据差距， 需要通过未来的动物和/或人类研究来填补。神经科学 目的是：1）建立耳蜗功能的综合模型，2） 开发噪声性听力损失模型，以及3）开发综合模型 声源定位。信息学的目标是：1）创建 用于基于网络的听觉建模环境的计算基础设施，2） 创建一个智能虚拟实验室， 模拟的重新配置和模型模块的互换，以及 参考信息，以帮助模拟设计，以及3）开发用户 用于模型配置和数据可视化界面。