ACTIVE FILTERING IN THE COCHLEA

这项研究的长期目标是证实， 细胞负责耳蜗中的机电放大 并阐明这种放大的潜在机制。的 该提案的具体目标是确定 Corti器官负责耳蜗频率图， 确定OHC如何放大行波，以确定 耳蜗分区的运动与IHC静纤毛运动耦合， 并确定耳声发射与耳蜗分区的关系 议案为了实现这些目标，研究人员将测量 机械阻抗的细胞和细胞外元素的 Corti器官，来描绘Corti器官的运动 响应于切除的耳蜗中的电刺激和机械刺激， 并同时测量基底膜运动、耳蜗 微音效应和耳声发射。的结果 建议的实验以及以前的实验 研究人员和其他人将被解释的援助计算 模型将使用两种类型的模型：微机械和 宏观力学的计算模型将基于物理， 可能的，并将包括机械的具体说明 Corti器、基底膜和顶盖的性质 膜，以及毛细胞机械电转导和OHC 能动性

The long term goal of the proposed research is to confirm that outer hair cells are responsible for electromechanical amplification in the cochlear and to clarify the underlying mechanisms of this amplification. The specific goals of the proposal are to determine which properties of the organ of Corti are responsible for the cochlear frequency map, to establish how the OHCs amplify the traveling wave, to determine how the motions of the cochlear partition is coupled to IHC stereocilia motion, and to establish how otacoustic emissions relate to the cochlea partition motion. To achieve these goals, the investigators will measure the mechanical impedance of the cellular and extracellular elements of the organ of Corti, to image the motion of the elements of the organ of Corti in response to electrical and mechanical stimulation in excised cochleas, and to simultaneously measure basilar membrane motion, cochlear microphonics, and otacoustic emissions in live animals. The results of the proposed experiments together with previous experiments by the investigators and others will be interpreted with the aid of computational models. Two types of models will be used: micromechanical and macromechanical. The computational models will be physically based as possible and will include specific descriptions of the mechanical properties of the organ of Corti, basilar membrane, and tectorial membrane, as well as hair-cell mechanoelectric transduction and OHC motility.