ACTIVE FILTERING IN THE COCHLEA

耳蜗的主动过滤

• 批准号: 6515982
• 负责人: David C. Mountain
• 金额: $ 34.34万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515982
• 关键词: auditory stimulus; biological signal transduction; biomechanics; cell motility; cochlear microphonic potentials; ear hair cell; efferent nerve; electrostimulus; gerbil /jird; guinea pigs; hearing; mathematical model; otoacoustic emission; sound frequency; vibration

The long term goal of the proposed research is to confirm that outer hair cells are responsible for electromechanical amplification in the cochlear and to clarify the underlying mechanisms of this amplification. The specific goals of the proposal are to determine which properties of the organ of Corti are responsible for the cochlear frequency map, to establish how the OHCs amplify the traveling wave, to determine how the motions of the cochlear partition is coupled to IHC stereocilia motion, and to establish how otacoustic emissions relate to the cochlea partition motion. To achieve these goals, the investigators will measure the mechanical impedance of the cellular and extracellular elements of the organ of Corti, to image the motion of the elements of the organ of Corti in response to electrical and mechanical stimulation in excised cochleas, and to simultaneously measure basilar membrane motion, cochlear microphonics, and otacoustic emissions in live animals. The results of the proposed experiments together with previous experiments by the investigators and others will be interpreted with the aid of computational models. Two types of models will be used: micromechanical and macromechanical. The computational models will be physically based as possible and will include specific descriptions of the mechanical properties of the organ of Corti, basilar membrane, and tectorial membrane, as well as hair-cell mechanoelectric transduction and OHC motility.

拟议研究的长期目标是确认外发 细胞负责人工耳蜗中的机电扩增 并阐明这种扩增的基本机制。这 该提案的具体目标是确定 Corti器官负责人耳蜗频率图， 确定OHC如何放大行驶波，以确定 耳蜗分区的运动与IHC立体胶体运动耦合， 并确定耳端排放与耳蜗分区的关系 运动。为了实现这些目标，调查人员将衡量 细胞和细胞外元件的机械阻抗 Corti的器官，以形象成像Corti器官元素的运动 响应于切除的耳蜗中的电和机械刺激， 并同时测量基底膜运动，人工耳蜗 活动物中的麦克风和耳端排放。结果 提出的实验以及先前的实验 调查人员和其他人将在计算的帮助下进行解释 型号。将使用两种类型的模型：微机械和 大力学。计算模型将以物理为基础 可能的并将包括机械的特定描述 Corti，基底膜和Tecorial的器官的特性 膜以及发型机械电的转导和OHC 运动。