ADAPTION OF SPATIAL ORIENTATION IN LOCOMOTION & POSTURE

运动空间方向的适应

• 批准号: 6362910
• 负责人: FAY BAHLING HORAK
• 金额: $ 34.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6362910
• 关键词: balance; behavioral /social science research tag; biomechanics; chordate locomotion; clinical research; exercise; gait; human subject; posture; proprioception /kinesthesia; sensorimotor system; space perception; vestibular apparatus; visual perception

DESCRIPTION: (adapted from Investigator's abstract) The long-term goal of this project is to understand the adaptive mechanisms underlying control of postural orientation and equilibrium in stance and gait in order to ameliorate balance and gait disorders. Loss of sensory information in patients with neurological deficits and in the elderly result in problems with gait and balance, and the investigators hypothesize that by manipulating somatosensory information from the support surface they can reveal how somatosensory and vestibular information interact in balance and gait and gain insight into compensation for sensory loss. Specific Aim I: How do bilateral vestibular loss patients use somatosensory information for postural orientation and equilibrium during gait? Recent studies have shown that stepping-in-place on a circular treadmill ("podokinetic stimulation") produces adaptations in locomotor trajectories in normal subjects. The investigators will use adaptation to podokinetic stimulation to reveal how subjects with bilateral vestibular loss use somatosensory information to control navigation trajectories and equilibrium during locomotion. They hypothesize that loss of vestibular information increases reliance on the somatosensory/motor system for spatial orientation and equilibrium. Specific Aim II: Can repeated exposures to podokinetic stimulation result in changes in postural orientation for gait in normal subjects and patients with unilateral vestibular loss? The Investigators hypothesize that repeated exposure to podokinetic stimulation results in enhanced and long-term retention of adaptation in normal subjects, and that podokinetic stimulation can be used to develop rehabilitation approaches for the curved locomotor trajectories and dysequilibrium observed in patients with unilateral vestibular loss. Specific Aim III: What is the effect of adapting to stance on inclined surfaces on postural orientation in healthy subjects and subjects with vestibular loss? The investigators will characterize the long-term effects of adaptation to stance on inclined surfaces in vestibular loss and control patients to reveal the contribution of the somatosensory-motor system to postural orientation. They hypothesize that patients with loss of vestibular (especially otolith) function will demonstrate larger changes in both postural orientation and perceived tilt than normal controls and that active motor control is necessary for adaptation to inclined surfaces. A better understanding of how the somatosensory/motor system, together with the vestibular system, contributes to locomotion and stance posture will allow them to better identify and rehabilitate deficits in balance and gait.

描述：（改编自研究者摘要）本研究的长期目标 该项目旨在了解姿势控制的适应机制， 姿势和步态的方向和平衡，以改善平衡 和步态障碍。神经系统疾病患者的感觉信息丢失 缺陷和老年人导致步态和平衡问题， 研究人员假设，通过操纵来自 它们可以揭示躯体感觉和前庭 信息在平衡和步态中相互作用， 感觉丧失 具体目标I：双侧前庭功能丧失患者如何使用体感 步态过程中姿势定向和平衡的信息？最近 研究表明，在圆形跑步机上原地踏步（“足动”） 刺激”）在正常的运动轨迹中产生适应性 科目研究者将使用对足动刺激的适应， 揭示了双侧前庭功能丧失的受试者如何利用体感 控制导航轨迹和平衡的信息， 运动他们假设前庭信息的丢失会增加 依赖躯体感觉/运动系统进行空间定向， 均衡 具体目标II：反复暴露于足动力刺激是否会导致 正常人和患者步态姿势方向的变化 单侧前庭功能丧失研究人员假设，重复 暴露于足动力刺激导致增强的和长期的保留 正常受试者的适应性，以及足动刺激可以用于 为弯曲的运动轨迹开发康复方法， 在单侧前庭丧失的患者中观察到平衡障碍。 具体目标III：在倾斜表面上适应站立的效果如何 对健康受试者和前庭丧失受试者的姿势定向的影响？ 研究人员将描述适应的长期影响， 前庭丧失和控制患者的倾斜表面站立， 躯体感觉-运动系统对姿势定向的贡献。 他们假设前庭（尤其是耳石）缺失的患者 功能将在姿势方向和 感知倾斜比正常对照组和积极的运动控制是必要的 以适应倾斜表面。 更好地理解躯体感觉/运动系统如何与 前庭系统，有助于运动和站立姿势将允许他们 以更好地识别和修复平衡和步态缺陷。