A Short Instrumented Test of Mobility for Neurological Disorders

描述（由申请人提供）：平衡不良是数百万慢性神经系统疾病患者以及许多老年人死亡和生活质量下降的最常见原因。没有成本效益，便携式系统目前可用于允许临床医生客观地量化在临床环境中的姿势踏步反应。我们公司APDM的长期目标是将最先进的临床系统商业化，以使用我们的核心技术来测量移动障碍：世界上最先进的无线，同步，身体佩戴的惯性传感器Opals（APDM.com）。本阶段I应用的目的是确定使用这些传感器开发与跌倒风险相关的极短平衡和步态测试的可行性。具体目标是：开发自动度量算法和仪器站立和行走测试（ISAW）的复合“跌倒风险评分”。目标I的目的是开发和测试帕金森病患者1分钟平衡和步态测试的有效性和可靠性。Aim II.将ISAW集成到移动实验室系统的专有用户界面中。Aim II的目标是建立一个创新的计算机用户界面，使临床医生能够快速，准确，安全和可靠地测试姿势控制的3个方面：站立期间的摇摆：姿势摇摆，预期姿势调整，以及步态和转弯期间的动态平衡，在短短的1分钟测试中。我们最初将为帕金森病患者开发移动实验室，因为他们比任何其他神经系统疾病都有更多的福尔斯，但我们相信，这个工具将有助于物理治疗师和临床医生和临床试验人员处理任何形式的移动残疾，如多发性硬化症，中风，头部损伤，发育障碍，多感觉障碍，体弱的老年人，第一阶段的应用将决定ISAW试验的可行性。我们的II期申请将确定ISAW测试预测未来福尔斯的能力，其对轻度神经系统疾病的敏感性和特异性，对药物的反应性，以及ISAW对更广泛的神经平衡障碍和老年跌倒者的安全性，为广泛的市场营销做准备。

DESCRIPTION (provided by applicant): Poor balance is the most common source of mortality and reduced quality of life for the millions of people with chronic, neurological disease as well a many elderly people. No cost-effective, portable system is currently available to allow clinicians to objectively quantify postural stepping responses in a clinical environment. The long-term goal of our company, APDM, is to commercialize a state-of-the-art, clinical system to measure mobility disorders using our core technology: the world's most advanced wireless, synchronized, body-worn inertial sensors, the Opals (APDM.com). The objective of this Phase I application is to determine the feasibility of developing a very short balance and gait test related to fall risk using these sensors. The specific aims are: Aim I. To develop algorithms for automatic metrics and a composite 'Fall Risk score' from the Instrumented Stand and Walk Test (ISAW). The objective of Aim I is to develop and test the validity and reliability of a 1-minute balance and gait test for patients with Parkinson's disease. Aim II. To integrate the ISAW into the proprietary user-interface of the Mobility Lab system. The objective of Aim II is to build an innovative, computer user-interface that allows clinicians to quickly, accurately, safely and reliably test 3 aspects of postural control: sway during stance: postural sway, anticipatory postural adjustments, and dynamic balance during gait and turning in a short, 1-minute test. We will initially develop Mobility Lab for patients with Parkinson's disease because they have more falls than any other neurological disorder, but we are confident that this tool will be useful for physical therapists and clinicians and clinical trialists working with any form of mobility disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. This Phase I application will determine the feasibility of the ISAW test. Our Phase II application will then determine how well the ISAW test predicts future falls, its sensitivity and specificity to mild neurological disease, responsiveness to medication, and safety of the ISAW for a wider range of neurological balance disorders and elderly fallers, in preparation for widespread marketing.