A novel role for CBF? as a regulator of breast cancer

CBF 的新角色？

• 批准号: nhmrc : 1069593
• 负责人: A/Pr Matthew Naylor
• 金额: $ 45.5万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-role-cbf-breast-cancer/455402
• 关键词: novel; role; CBF; regulator; breast

Whole genome sequencing studies of human breast tumours identified a handful of common significantly mutated genes, all previously linked to breast cancer, except one, CBF?. Preliminary data from our lab now show that CBF? may be a new regulator of human breast cancer and metastasis. Using mice with altered CBF? levels, breast cancer models and human patient cohorts, this study aims to identify a novel role for CBF? as a new regulator of human breast cancer and potential therapeutic target.

对人类乳腺肿瘤的全基因组测序研究发现了一些常见的显著突变基因，这些基因以前都与乳腺癌有关，除了CBF？。我们实验室的初步数据显示CBF？可能是人类乳腺癌及其转移的一个新的调节因子。使用脑血流量改变的小鼠？水平，乳腺癌模型和人类患者队列，这项研究的目的是确定一个新的作用CBF？作为一种新的乳腺癌调节因子和潜在的治疗靶点。