ELF5 integrates prolactin and progestin control of mammary gland development via regulation of progenitor cells.

ELF5 通过调节祖细胞整合催乳素和孕激素对乳腺发育的控制。

• 批准号: nhmrc : 481345
• 负责人: A/Pr Matthew Naylor
• 金额: $ 48.04万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elf5-integrates-prolactin-progenitor-cells/96009
• 关键词: ELF5; integrates; prolactin; progestin; control

Elf5 may act as a master-regulator of mammary cell growth during pregnancy. We will demonstrate that Elf5 can replace the requirement for prolactin and progesterone to trigger mammary development and we will determine the stem or progenitor cells Elf5 acts on. Finally we will apply this knowledge to breast cancer cell lines to discover what role Elf5 plays in breast cancer. These experiments have the potential to establish Elf5 as a new therapeutic target for the treatment of breast cancer.

Elf5 可能充当怀孕期间乳腺细胞生长的主调节因子。我们将证明Elf5可以替代催乳素和黄体酮的需求来触发乳腺发育，并且我们将确定Elf5作用的干细胞或祖细胞。最后，我们将把这些知识应用到乳腺癌细胞系中，以发现Elf5在乳腺癌中发挥的作用。这些实验有可能将Elf5确立为治疗乳腺癌的新治疗靶点。