Role of integrin signalling in breast and prostate cancer

整合素信号在乳腺癌和前列腺癌中的作用

• 批准号: nhmrc : 535904
• 负责人: A/Pr Matthew Naylor
• 金额: $ 27.47万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-integrin-signalling-prostate-cancer/115846
• 关键词: Role; integrin; signalling; breast; prostate

Integrins have an essential role in the control of mammary gland development and cell function. During tumour progression, integrins enable cancer cells to detach, proliferate, migrate and survive during metastasis. To test whether integrins regulate breast and prostate tumour progression, mice with mammary or prostate specific integrin deletion will be crossed with mice engineered to develop cancer. The effects of integrin loss on tumour growth and metastasis will be determined.

整合素在控制乳腺发育和细胞功能中起着重要作用。在肿瘤的发展过程中，整合素使癌细胞能够在转移过程中分离、增殖、迁移和存活。为了测试整合素是否调节乳腺癌和前列腺癌的进展，将带有乳腺或前列腺特异性整合素缺失的小鼠与转基因小鼠进行杂交，以发展成癌症。整合素缺失对肿瘤生长和转移的影响将被确定。