AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
基本信息
- 批准号:6362939
- 负责人:
- 金额:$ 13.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-03-01 至 2004-02-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Amorphous calcium phosphate (ACP), a key precursor in the biological formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs). ACP, however, has two properties that justify its utilization as a possible remineralizing agent: it is one of the most soluble of all the biologically important CaPs, and it exhibits the most rapid conversion to HAP. Recently we developed unique polymeric dental composites/sealants that utilized these properties of ACP to remineralize bovine enamel lesions in vitro. However, as currently formulated, these ACP composites have relatively low mechanical strength and adhesiveness to teeth. Such shortcomings may limit their wider utilization in dentistry. The objectives of this proposal are (1) to develop effective remineralizing dental composites based on ACP that will have optimal mechanical and adhesive properties while maintaining sustained release of Ca and PO4 ions, and (2) to enhance our understanding of the remineralizing behavior of these ACP-based materials, especially the major factors that control Ca and PO4 ion release and redeposition into HAP. To accomplish these objectives we propose to: l] prepare ACP fillers with structurally incorporated silica, zirconia, and/or titania; 2] develop surface- modified hybrid ACP fillers amenable to treatment by silane coupling agents; 3] explore the effects of resin composition on the, mechanical and physicochemical properties of ACP-composites, and 4] evaluate the effects of bifunctional methacrylates on the adhesion of the composites to tooth substrates. It is expected that this research will both advance our fimdamenta1 understanding of these novel bioactive composites and eventually lead to clinically useful products. The extended, time-releasing nature of these ACP based polymeric materials should be especially useful in dental sealant and adhesive applications for preventing demineralization or promoting remineralization.
无定形磷酸钙(ACP)是羟基磷灰石(HAP)生物形成的关键前体,作为一种牙科材料,其受到的关注不如结晶磷酸钙(CaPs)。然而,ACP有两个特性证明它有可能被用作再矿化剂:它是所有重要的生物cap中最易溶解的一种,并且它向HAP的转化速度最快。最近,我们开发了独特的聚合物牙科复合材料/密封剂,利用ACP的这些特性在体外对牛牙釉质病变进行再矿化。然而,按照目前的配方,这些ACP复合材料具有相对较低的机械强度和对牙齿的粘附性。这些缺点可能会限制其在牙科中的广泛应用。本研究的目标是:(1)开发基于ACP的有效再矿化牙科复合材料,使其在保持Ca和PO4离子持续释放的同时具有最佳的机械和粘合性能;(2)增强我们对这些ACP基材料再矿化行为的理解,特别是控制Ca和PO4离子释放和再沉积到HAP中的主要因素。为了实现这些目标,我们建议:1]用结构上掺入的二氧化硅、氧化锆和/或二氧化钛制备ACP填料;2]研制适合硅烷偶联剂处理的表面改性杂化ACP填料;3]探讨树脂组成对acp -复合材料力学和物理化学性能的影响;4]评价双功能甲基丙烯酸酯对复合材料与牙齿基质粘附的影响。预计这项研究将促进我们对这些新型生物活性复合材料的基本了解,并最终导致临床有用的产品。这些ACP基高分子材料的延展性和缓释性在牙密封剂和粘合剂中尤其有用,可以防止脱矿或促进再矿化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DRAGO SKRTIC其他文献
DRAGO SKRTIC的其他文献
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{{ truncateString('DRAGO SKRTIC', 18)}}的其他基金
ANTIMICROBIAL AND REMINERALIZING COMPOSITES FOR CLASS V RESTORATIONS
用于 V 级修复的抗菌和再矿化复合材料
- 批准号:
9302373 - 财政年份:2016
- 资助金额:
$ 13.9万 - 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
- 批准号:
7755851 - 财政年份:2000
- 资助金额:
$ 13.9万 - 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
- 批准号:
7459277 - 财政年份:2000
- 资助金额:
$ 13.9万 - 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
- 批准号:
8005032 - 财政年份:2000
- 资助金额:
$ 13.9万 - 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
- 批准号:
7567522 - 财政年份:2000
- 资助金额:
$ 13.9万 - 项目类别: