AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS

无定形磷酸钙牙科材料

基本信息

  • 批准号:
    7008228
  • 负责人:
  • 金额:
    $ 29.3万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-03-01 至 2008-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: Our research for the last 4 years (grant DE13169) with amorphous calcium phosphate (ACP)-based Dental composites has resulted in biocompatible composites with demineralizing ability, moderately improved mechanical strength and adhesiveness to tooth structures. Nevertheless, current ACP composites have less than optimal filler/matrix cohesion and adsorb water excessively. These factors can have adverse effects on the physicochemical and mechanical properties of these materials, and thereby limit their clinical applicability. This application outlines our research for improving the physical and antidemineralizing/ demineralizing properties of ACP composites to where they can be used in a broad variety of applications where caries control and reversal is desired. The main objectives of this application are: [1] to further study structure/composition/property relationships of ACP fillers to develop strategies that better control the dispersion of ACP in the polymer matrix, [2] investigate intracomposite filler/organic matrix interactions and composite/tooth interactions to determine the mechanisms that control mineral redeposition from these composites and [3] to extend the utility of ACP to remineralizing orthodontic adhesives. To accomplish these objectives we propose to: (a) assess the role of foreign ions/molecules in controlling the particle size, compositional and structural properties of ACP fillers while maintaining chemical stability to prevent premature intra-composite conversion to non-ion releasing crystalline apatite, (b) elucidate interfacial coupling and polymer grafting reactions as a route to enhance the interfacial strength between the ACP and the polymeric matrix, and (c) evaluate ACP-composites designed for orthodontic applications for their in vitro remineralization ability and bonding properties. The proposed research is expected to provide the new experimental evidence needed to advance our understanding of the fundamental mechanisms that govern dissolution/reprecipitation of the ACP filler and, consequently, the demineralizing ability of ACP-based Dental materials. The proposed studies should lead to the design of ACP composites for a variety of Dental applications and the formulation of a prototype orthodontic cement that is suitable for clinical evaluation.
描述:我们在过去四年(授予DE13169)对无定形磷酸钙(ACP)基牙科复合材料的研究已经产生了具有脱矿能力、适度提高机械强度和对牙齿结构的粘附性的生物相容性复合材料。然而,目前ACP复合材料的填料/基质结合力较差,吸水过多。这些因素可能会对这些材料的物理化学和机械性能产生不利影响,从而限制其临床应用。本申请概述了我们的研究,旨在提高ACP复合材料的物理性能和抗脱矿/脱矿性能,使其可用于各种需要控制和逆转龋齿的应用。 这项应用的主要目标是:[1]进一步研究ACP填料的结构/组成/性能关系,以开发更好地控制ACP在聚合物基质中分散的策略,[2]研究复合材料内填料/有机基质相互作用和复合材料/牙齿相互作用,以确定控制这些复合材料中矿物再沉积的机制,以及[3]扩展ACP在正畸粘结剂再矿化中的用途。为了实现这些目标,我们建议:(A)评估外来离子/分子在控制ACP填料的粒度、组成和结构性能方面的作用,同时保持化学稳定性,以防止复合材料内过早转变为非离子释放的结晶型磷灰石;(B)阐明界面偶联和聚合物接枝反应作为增强ACP与聚合物基质之间界面强度的途径,以及(C)评估为正畸应用设计的ACP复合材料的体外再矿化能力和粘接性能。这项拟议的研究有望提供新的实验证据,以促进我们对ACP填充物溶解/再沉淀的基本机制的理解,从而促进ACP基牙科材料的脱矿能力。建议的研究将导致设计适用于各种牙科应用的ACP复合材料,并研制出适合临床评估的正畸粘固剂原型。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DRAGO SKRTIC其他文献

DRAGO SKRTIC的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DRAGO SKRTIC', 18)}}的其他基金

ANTIMICROBIAL AND REMINERALIZING COMPOSITES FOR CLASS V RESTORATIONS
用于 V 级修复的抗菌和再矿化复合材料
  • 批准号:
    9302373
  • 财政年份:
    2016
  • 资助金额:
    $ 29.3万
  • 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
  • 批准号:
    7755851
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
  • 批准号:
    6044800
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
  • 批准号:
    6362939
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
  • 批准号:
    7459277
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
  • 批准号:
    6516549
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
  • 批准号:
    6727811
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
无定形磷酸钙牙科材料
  • 批准号:
    6634656
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
  • 批准号:
    8005032
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:
Amorphous calcium phosphate based dental materials
无定形磷酸钙基牙科材料
  • 批准号:
    7567522
  • 财政年份:
    2000
  • 资助金额:
    $ 29.3万
  • 项目类别:

相似海外基金

ASD3MAP: Amorphous Solid Dispersion Digital Design and Manufacturing Platform for rapid and resource-efficient development of bioavailable medicines
ASD3MAP:非晶固体分散体数字设计和制造平台,用于快速、资源高效地开发生物可利用药物
  • 批准号:
    10078996
  • 财政年份:
    2023
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Collaborative R&D
Co-Processing of Amorphous Solid Dispersions via Co-precipitation
通过共沉淀共处理非晶固体分散体
  • 批准号:
    2890503
  • 财政年份:
    2023
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Studentship
Enhanced Solid-State Nuclear Magnetic Resonance Spectroscopy of Amorphous Solid Dispersions for Pharmaceutical Sciences
用于制药科学的非晶固体分散体的增强型固态核磁共振波谱分析
  • 批准号:
    2889117
  • 财政年份:
    2023
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Studentship
Amorphous Solid Solutions in Glassy Hydrogels for Enhancing the Delivery of Poorly Soluble Drugs
玻璃状水凝胶中的无定形固溶体增强难溶性药物的递送
  • 批准号:
    RGPIN-2019-05459
  • 财政年份:
    2022
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Discovery Grants Program - Individual
Enhanced Solid-State NMR of Amorphous Solid Dispersion in Pharmaceutical Sciences
药物科学中非晶固体分散体的增强型固态核磁共振
  • 批准号:
    2599498
  • 财政年份:
    2021
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Studentship
Sustained release nanofiber formulation technology for amorphous solid dispersion
无定形固体分散体缓释纳米纤维制剂技术
  • 批准号:
    21K06516
  • 财政年份:
    2021
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Amorphous Solid Solutions in Glassy Hydrogels for Enhancing the Delivery of Poorly Soluble Drugs
玻璃状水凝胶中的无定形固溶体增强难溶性药物的递送
  • 批准号:
    RGPIN-2019-05459
  • 财政年份:
    2021
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Discovery Grants Program - Individual
Amorphous Solid Solutions in Glassy Hydrogels for Enhancing the Delivery of Poorly Soluble Drugs
玻璃状水凝胶中的无定形固溶体增强难溶性药物的递送
  • 批准号:
    RGPIN-2019-05459
  • 财政年份:
    2020
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Discovery Grants Program - Individual
Amorphous Solid Solutions in Glassy Hydrogels for Enhancing the Delivery of Poorly Soluble Drugs
玻璃状水凝胶中的无定形固溶体增强难溶性药物的递送
  • 批准号:
    RGPIN-2019-05459
  • 财政年份:
    2019
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Discovery Grants Program - Individual
Investigation of Crystallization of Poorly Water Soluble Drug in Amorphous Solid Dispersion during Dissolution
难溶性药物在无定形固体分散体中溶解过程中结晶的研究
  • 批准号:
    518713-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 29.3万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了