AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS

产品说明：我们在过去4年中对无定形磷酸钙（ACP）基牙科复合材料的研究（授予DE 13169）已经产生了具有脱矿能力、适度改善机械强度和牙齿结构的生物相容性复合材料。然而，目前的ACP复合材料具有低于最佳的填料/基质内聚性并且过度地吸收水。这些因素可能对这些材料的物理化学和机械性能产生不利影响，从而限制其临床适用性。本申请概述了我们对改善ACP复合材料的物理和抗脱矿/脱矿性能的研究，使其可用于需要龋齿控制和逆转的各种应用中。 本申请的主要目的是：[1]为了进一步研究ACP填料的结构/组成/性能关系以开发更好地控制ACP在聚合物基质中的分散的策略，[2]研究复合材料内填料/有机基质相互作用和复合材料/牙齿相互作用，以确定控制这些复合材料中矿物再沉积的机制，[3]将ACP的应用扩展到使正畸粘合剂固化。为实现这些目标，我们建议：（a）评估外来离子/分子在控制ACP填料的粒度、组成和结构性质同时保持化学稳定性以防止过早的复合材料内转化为非离子释放结晶磷灰石中的作用，（B）阐明界面偶联和聚合物接枝反应作为增强ACP和聚合物基质之间的界面强度的途径，以及（c）评估为正畸应用设计的ACP复合材料的体外再矿化能力和粘结性能。预计拟议的研究将提供新的实验证据，以促进我们对ACP填料溶解/再沉淀的基本机制的理解，从而提高ACP基牙科材料的脱矿能力。拟议的研究应导致ACP复合材料的设计，用于各种牙科应用和制定一个原型正畸水泥，是适合临床评价。

DESCRIPTION: Our research for the last 4 years (grant DE13169) with amorphous calcium phosphate (ACP)-based Dental composites has resulted in biocompatible composites with demineralizing ability, moderately improved mechanical strength and adhesiveness to tooth structures. Nevertheless, current ACP composites have less than optimal filler/matrix cohesion and adsorb water excessively. These factors can have adverse effects on the physicochemical and mechanical properties of these materials, and thereby limit their clinical applicability. This application outlines our research for improving the physical and antidemineralizing/ demineralizing properties of ACP composites to where they can be used in a broad variety of applications where caries control and reversal is desired. The main objectives of this application are: [1] to further study structure/composition/property relationships of ACP fillers to develop strategies that better control the dispersion of ACP in the polymer matrix, [2] investigate intracomposite filler/organic matrix interactions and composite/tooth interactions to determine the mechanisms that control mineral redeposition from these composites and [3] to extend the utility of ACP to remineralizing orthodontic adhesives. To accomplish these objectives we propose to: (a) assess the role of foreign ions/molecules in controlling the particle size, compositional and structural properties of ACP fillers while maintaining chemical stability to prevent premature intra-composite conversion to non-ion releasing crystalline apatite, (b) elucidate interfacial coupling and polymer grafting reactions as a route to enhance the interfacial strength between the ACP and the polymeric matrix, and (c) evaluate ACP-composites designed for orthodontic applications for their in vitro remineralization ability and bonding properties. The proposed research is expected to provide the new experimental evidence needed to advance our understanding of the fundamental mechanisms that govern dissolution/reprecipitation of the ACP filler and, consequently, the demineralizing ability of ACP-based Dental materials. The proposed studies should lead to the design of ACP composites for a variety of Dental applications and the formulation of a prototype orthodontic cement that is suitable for clinical evaluation.