UPGRADE OF A 4.7T/40CM GE OMEGA CSI NMR SPECTROMETER

4.7T/40CM GE OMEGA CSI NMR 光谱仪的升级

• 批准号: 6288081
• 负责人: VADAPPURAM P CHACKO
• 金额: $ 50万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-26 至 2002-03-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288081
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

High magnetic fields are essential for optimized signal to noise ratio and spectral resolution in NMR. To this end, a 4.7T/40cm General Electric MR instrument was purchased 1986 by Johns Hopkins University School of Medicine for biomedical research on a variety of animal models. Since this instrument was one of the earliest models in this class of instruments, it was upgraded to then state-of-the-art capabilities in 1991, with funds from the NCRR Shared Instrumentation Grant Program. The upgraded Omega console with its accessories has performed superbly well and served the NMR community in and around Johns Hopkins for nearly ten years now. However, the present instrument has become out-dated and very difficult to service and maintain in good working condition. Consequently this proposal requests an upgrade of this instrument to keep it at the cutting edge of NMR technology. The present console is outdated and very restrictive with regards to graphic prescription, data processing and display, and data storage. We are requesting the complete replacement of the existing console with a modem BioSpec(Avance) console along with a new B-GA12 actively shielded gradient set from Bruker Instruments. These improvements are essential for the continued development of spatially localized spectroscopy and imaging for a variety of studies in oncology, cardiology, radiology and neurology at Johns Hopkins Medical Institutions.

高磁场对于NMR中的最佳信噪比和光谱分辨率是必不可少的。为此，约翰霍普金斯大学医学院于1986年购买了4.7 T/40 cm通用电气MR仪器，用于各种动物模型的生物医学研究。由于这台仪器是这类仪器中最早的型号之一，因此在1991年，在NCRR共享仪器赠款计划的资助下，它被升级为当时最先进的能力。升级后的Omega控制台及其配件表现出色，为约翰·霍普金斯及其周边地区的核磁共振社区服务了近十年。然而，目前的仪器已经过时，很难维修和保持良好的工作状态。因此，该提案要求升级该仪器，以使其保持在核磁共振技术的前沿。目前的控制台是过时的，并且在图形规定、数据处理和显示以及数据存储方面具有很大的限制性。我们要求将现有控制台完全更换为现代BioSpec（Avance）控制台，沿着更换为Bruker Instruments的新型B-GA 12主动屏蔽梯度套件。这些改进对于约翰霍普金斯医疗机构的肿瘤学、心脏病学、放射学和神经学的各种研究的空间定位光谱学和成像的持续发展至关重要。