QUALITY OF LIFE IN ALZHEIMERS DISEASE

描述(改编自调查者摘要)： 拟议的调查是纵向评估中国人的生活质量 阿尔茨海默病(AD)的个体和识别变量 影响这一人群的生活质量。拟议的调查是基于 成人发展的符号互动和交易理论，以及 提出了一种AD患者的生活质量模型，该模型同时包括个体和 环境特征，集客观和主观于一体 对患者生活质量的评估。它建立在调查员之前的 评估AD患者抑郁、愉快事件、行为的研究 问题；照顾者的压力和反应性；以及人际关系 AD患者与家庭照顾者之间的问题；以及对生活质量的影响 慢性病和老年人的文学作品。 调查有两个目的。目标1是开发和管理 40例社区AD患者生活质量测评及相关因素分析 家庭照顾者。心理测量数据，包括内部一致性， 重测信度和评分者间信度、内容效度和结构效度 将根据患者和护理者的报告进行评估。 目标2是对总共200名患者的生活质量变化的纵向调查 居住在社区的AD患者。科目将每六个月重新评估一次 在三年的时间段内持续几个月。在目标1中发展的生活质量测量 将与其他属性的评估一起管理 假设与生活质量有关，包括患者和照顾者 人口统计学特征；患者认知、功能和健康状况 状态；行为问题和情绪；照顾者的负担和情绪；以及 病人与护理者之间的人际关系。 调查结果将提供：(A)评估AD的措施 患者的生活质量；(B)作为认知的患者生活质量变化的评估 随着时间的推移和疾病的进展，功能会下降； 患者生活质量与其他重要患者及照顾者的关系 特点。通过识别可预测生活质量变化的变量， 这项调查将有助于制定干预措施，以 最大化AD患者的生活质量。

DESCRIPTION (Adapted from Investigator's abstract): The goal of the proposed investigation is to longitudinally assess quality of life (QOL) in individuals with Alzheimer's Disease (AD) and to identify variables that influence QOL in this population. The proposed investigation is based on symbolic interaction and transactional theories of adult development, and proposes a model of QOL in AD that includes both individual and environmental characteristics and incorporates objective and subjective assessments of patient QOL. It builds upon the investigator's prior research evaluating AD patient depression, pleasant events, behavior problems; caregiver stress and reactivity; and interpersonal relationship issues between AD patients and family caregivers; as well as on the QOL literature in chronic illness and the elderly. The investigation has two aims. Aim 1 is to develop and administer and assessment of patient QOL to 40 community-residing AD patients and their family caregivers. Psychometric data, including internal consistency, test-retest and inter-rater reliability, and content and construct validity will be evaluated for both patient and caregiver reports. Aim 2 is a longitudinal investigation of changes in QOL in a total of 200 community-residing AD patients. Subjects will be re-evaluated every six months over a three-year time period. The QOL measure developed in Aim 1 will be administered, along with assessments of other attributes hypothesized to be related to QOL, including patient and caregiver demographic characteristics; patient cognitive, functional, and health status; behavioral problems and mood; caregiver burden and mood; and patient-caregiver interpersonal relationship. Results of the investigation will provide: (a) a measure for evaluating AD patients' QOL; (b) an evaluation of changes in patient QOL as cognitive functioning declines over time and disease progression; and an analysis of the relationship of patient QOL with other important patient and caregiver characteristics. By identifying variables that may predict changes in QOL, this investigation will assist in the development of interventions to maximize AD patients' QOL.