Building a Sustainable Indian Tribal Infrastructure for Translational Research

描述（由申请人提供）：美国印第安人和阿拉斯加原住民（AI/AN）社区在健康差距方面承担着沉重的负担。虽然健康促进计划已在AI/AN社区实施，但基于证据的行为科学转化研究很少。时间，金钱和资源成本，不信任的历史，以及缺乏准备充分的研究人员在部落社区工作是公认的挑战，在这些群体内的研究。需要建立支持学术和部落研究伙伴关系的组织结构，以建立部落能力，并使护士和其他卫生研究人员能够与部落合作进行转化研究。该项目的目标是建立一个学术健康中心（护理的UW学校）和两个农村部落（Suquamish和港甘布尔S 'Klallam）之间的伙伴关系基础设施，以提高部落的能力，从事行为科学转化研究。该计划将借鉴社会学习理论，并采用基于社区的参与式研究（CBPR）的方法，以帮助部落概念化，规划和提交基于证据的翻译赠款他们的社区。这项工作将分三个阶段进行。在第一阶段，将成立一个由部落领袖、社区代表和学术学者组成的咨询委员会，每个部落的社区研究助理将在每个部落内建立规划小组，评估研究和培训需求。使用CBPR过程中，这些群体将确定部落优先研究领域，包括（但不限于）：癌症筛查和预防，心理健康，和/或促进身体活动和健康的生活方式在老年人。在第二阶段，部落成员，学生，护理人员和来自华盛顿大学的专家将在研究培训和指导计划中合作，该计划在准备研究提案的所有步骤中提供正式指导和实践援助。在第三阶段，这支由部落成员、学生和学术人员组成的训练有素的骨干队伍将支持部落制定并提交至少一至两笔小额赠款和一份R 01，以满足已确定的需求。该计划的评估包括基于既定计划目标的过程和结果措施。研究结果将推动CBPR作为基础设施建设方法的科学和理解，为减少这些服务不足的社区的健康差距做出宝贵贡献，并提供急需的学术/部落合作模式。将通过以下方式促进可持续性：1）在部落和华盛顿大学护理学院内发展与现有结构相联系的基础设施和政策; 2）建立与社区机构和大学内其他学校和部门的联系; 3）记录培训模块;以及4）部落与华盛顿大学护理学院和研究资金来源的基于网络的技术联系。 公共卫生相关性：这项提案涉及一个重大的公共卫生利益问题-减少美洲印第安人社区的健康差距。我们建议建立一个基础设施，为学术健康中心（UW护理学院）和部落社区（Suquamish和Pt。Gamble S 'Klallam）建立部落进行转化健康科学研究的能力，并为护士和其他健康研究人员提供与这些社区合作的机会。该项目的最终目标是建设开展研究的能力，以便向这些服务不足的社区提供更多文化上适当的、最先进的、以证据为基础的保健服务。

DESCRIPTION (provided by applicant): American Indian and Alaska Native (AI/AN) communities shoulder heavy burdens in health disparities. While health promotion programs have been implemented in AI/AN communities, evidence-based behavioral science translational research is rare. Time, monetary and resource costs, a history of mistrust, and a lack of well prepared researchers to work in tribal communities are recognized challenges to research within these groups. Infrastructures to support academic and tribal partnerships in research are needed to build tribal capacity and prepare nurses and other health researchers to collaborate with tribes in translational research. The goal of this project is to establish a partnership infrastructure between an academic health center (the UW School of Nursing) and two rural tribes (Suquamish and Port Gamble S'Klallam) to enhance tribal capacity to engage in behavioral science translational research. The program will draw upon social learning theory and employ a community-based participatory research (CBPR) approach to assist the tribe in conceptualizing, planning, and submitting evidenced-based translational research grants for their communities. The work will be conducted in three phases. In phase one, an advisory committee comprised of tribal leaders, community representatives, and academic scholars will be established, and the Community Research Associate (CRA) in each tribe will establish planning teams within each tribe to assess needs for research and training. Using a CBPR process, these groups will identify tribal priorities for research in areas including (but not limited to): cancer screening and prevention, mental health, and/or promoting physical activity and healthy lifestyles in older adults. In phase two, tribal members, students, nursing faculty, and experts from the UW will collaborate in a research training and mentoring program that provides both formal instruction and hands-on assistance in all steps of preparing a research proposal. In phase three, this trained cadre of tribal members, students and academic faculty will support the tribes to develop and submit at least one to two small grants and one R01 to address identified needs. Evaluation of this program includes both process and outcome measures based on stated program objectives. Findings will advance the science and understanding of CBPR as an approach in infrastructure building, make valuable contributions to reducing health disparities for these underserved communities, and provide a much need academic/tribal model of collaboration in translational research. Sustainability will be facilitated by: 1) development of an infrastructure and policies within the tribes and the University of Washington School of Nursing that are linked to existing structures; 2) establishment of linkages to community agencies and other schools and departments within the University; 3) documented training modules; and 4) web based technology linkages of the tribes to the University of Washington School of Nursing and research funding sources. PUBLIC HEALTH RELEVANCE: This proposal addresses an issue of significant public health interest - reducing health disparities in American Indian communities. We propose to establish an infrastructure for a collaborative research partnership between an academic health center (UW School of Nursing) and tribal communities (Suquamish and Pt. Gamble S'Klallam) to build tribal capacity to conduct translational health sciences research, and to offer opportunities for nurses and other health researchers to collaborate with these communities. The ultimate goal of this project is to build capacity for conducting research to increase the availability of culturally appropriate, state-of-the-art, evidence based health care to these underserved communities.