CORE--REMEDIATION PRODUCT TOXICITY EVALUATION

生物和化学补救技术的优点是部分或完全降解超级基金化学品，而不是简单地从一个隔间转移到另一个隔间。这些技术的最终目标是将有毒化学品完全转化为其矿物最终产品，如CO2 C1-和H2O。然而，中间体通常是从超级基金化学品的部分转化中产生的。这些中间体可能具有足够的稳定性，因此它们在与风险评估和监管机构相关的时间范围内存在于环境中。传统上，补救是从母体化合物消失的角度来看待的，并假设这等同于一个更清洁和更安全的环境。然而，在补救过程中产生的稳定中间体，无论是作为单独的化合物和混合物，代表其环境中的存在。补救产品评价核心要检验的假设是，补救产品与母体化合物或混合物相比具有不同的生物活性。该核心将有助于整合补救项目的活动与项目调查人员寻求了解超级基金化学品及其补救产品的生物活性。在核心的支持下，将使用一系列测量各种生物功能的测定来生成和评估多氯联苯和多环芳烃混合物以及卤代溶剂和金属的修复产品。这将为更准确地评估补救技术以及如何改进这些技术提供基础，并为更全面地了解超级基金化学品及其补救产品发挥其生物作用的机制提供基础。

Biological and chemical remediation technologies offer the advantage of partial or complete degradation of Superfund chemical rather than simple transfer from one compartment to another. The ultimate goal of these technologies is the complete conversion of toxic chemicals to their mineral end products such as CO2 C1- and H20. Frequently however intermediates are produced from the partial transformation of Superfund chemicals. These intermediates may have sufficient stabilities so that they exist in the environment over time frame relevant to risk assessment and regulators. Traditionally, remediation is viewed from the standpoint of parent compound disappearance, and the assumption is that this equates to a cleaner and safer environment. However, stable intermediates produced during remediation, both as individual compounds and as mixtures representing their environmental occurrence. The hypothesis to be tested by the Remediation Product Evaluation Core is that the products of Remediation have different biologic activities compared to the parent compounds or mixtures. The Core will serve to integrate activities of remediation projects with project investigators seeking to understand the biologic activities of Superfund chemicals and their remediation products. Under auspices of the Core, remediation products of PCB and PAH mixtures and of halogenated solvents and metals will be generated and evaluated using an array of assays which measure a variety of biological functions. This will provide the basis of a more accurate assessment of remediation technologies and how to improve them, as well as a more complete understanding of the mechanisms by which Superfund chemicals and their remediation products exert their biological actions.