CLINICAL AND LABORATORY CORE

临床/实验室核心的牙科和医学临床医生将检查旧金山流行病学队列转诊的所有患者并验证诊断。根据这些转诊和其他转诊来源，他们将继续建立具有特定口腔病变患者的临床队列，以分析其与艾滋病发展和其他标志物/预测因素的关系。他们将为项目2、3和4中的研究从具有良好特征的口腔病变患者中获取活组织检查和其他样本。核心人员将负责临床研究患者记录，标本处理和储存，并将标本交给项目2、3和4的研究人员。他们将对涂片和切片进行染色，处理样本和活检组织标本，处理血液标本，维护病理和其他临床实验室数据，对爱泼斯坦-巴尔病毒进行原位杂交，以确认毛状白斑的诊断。临床/实验室核心研究人员将继续研究HIV感染口腔表现的临床和病理特征，并与项目1、2、3和4的研究人员一起，将继续报告新的特征，并探索其病因、发病机制、对治疗的反应以及宿主对口腔病原体的免疫反应。核心和项目研究人员的部分职责将是继续记录和发表这些发现，并构思和测试有关这一迷人而具有挑战性的疾病组的新假设。

The dental and medical clinicians of the Clinical/Laboratory Core will see all patients referred by the San Francisco epidemiology cohorts and validate diagnoses. From these referrals and other sources of patient referrals, they will continue to build clinical cohorts of patients with specific oral lesions in order to analyze their relationship to the development of AIDS and to other markers/predictors. They will obtain biopsies and other samples for the studies in Projects 2, 3, and 4 from well-characterized patients with the oral lesions being studied. The core staff will be responsible for clinical research patient records, for specimen handling and storage and for getting specimens to Project 2, 3, and 4 investigators. They will stain smears and sections, handle samples and biopsy tissue specimens, process blood specimens, maintain pathology and other clinical laboratory data, perform in situ hybridization for Epstein-Barr virus to confirm the diagnosis of hairy leukoplakia. The Clinical/Laboratory Core investigates will continues will continue to study the clinical and pathological features of the oral manifestations of HIV infection and, in conjunction with Project 1, 2, 3, and 4 investigators, will continue to report new features and to explore their etiology, pathogenesis, responsive to therapy, and host immune response to oral pathogens. Part of the responsibilities of the investigators in the Cores and the Projects will be to continue to document and publish such findings and to conceive and test new hypothesis concerning this fascinating and challenging group of diseases.