CORE--CLINICAL AND LABORATORY

核心——临床和实验室

• 批准号: 6104725
• 负责人: DEBORAH GREENSPAN
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104725
• 关键词: Candida albicans; Epstein Barr virus; HIV infections; biomedical facility; biopsy; candidiasis; clinical research; electron microscopy; human subject; immunocytochemistry; in situ hybridization; microorganism classification; oral health; oral leukoplakia; oral pharyngeal disorder; oral pharyngeal disorder diagnosis; patient /disease registry; tissue resource /registry

The dental and medical clinicians of the Clinical/Laboratory Core will see all patients referred by the San Francisco epidemiology cohorts and validate diagnoses. From these referrals and other sources of patient referrals, they will continue to build clinical cohorts of patients with specific oral lesions in order to analyze their repationship to the development of AIDS and to other markers/predictors. They will obtain biopsies and other samples for the studies in Projects 2 and 3 from well-characterized patients with the oral lesions being studied. The core staff will be responsible for clinical research pateints records, for speciment handling and storage and for getting speciments to Projects 2 and 3 investigators. They will stain smears and sections, handled samples and biopsy tissue speciments, maintain pathology and other clinical laboratory data, perform in situ hybridization for Epstein-Barr virus to confirm the diagnosis of hairy leukoplakia. Projects 2 and 3 will be using Core B for transmission electron microscopy and electron cytochemistry. The Clinical/Laboratory Core investigators will continue to study the clinical and pathological features of the oral manifestation of HIV infection and, in conjunction with Project 1, 2 and 3 investigators, will continue to report new features and to explore their etiology, pathogenesis and response to therapy. Part of the responsibilities of the investigators in the Cores and the Projects will be to continue to document and publish such new findings and to conceive and test new hypotheses concening this fascinating and challenging group of diseases.

临床/实验室核心的牙科和医学临床医生 会看到旧金山流行病学杂志转介的所有患者 队列和验证诊断。从这些转介和其他 患者转诊来源，他们将继续建立 口腔特殊病变患者的临床队列排序 分析其与艾滋病发病的关系，并探讨其与艾滋病发病的关系 其他标记物/预测物。他们将得到活组织检查和其他 项目2和项目3的研究样本来自 具有良好特征的患者，口腔损害正在研究中。 核心工作人员将负责临床研究申请 记录，用于标本处理和存储以及获取 将标本交给项目2和项目3的调查人员。他们会弄脏的 涂片和切片、处理过的样本和活组织 标本，维持病理学和其他临床实验室 数据，进行EB病毒的原位杂交，以 确认毛状白斑的诊断。项目2和项目3 将使用内核B进行透射电子显微镜检查， 电子细胞化学。临床/实验室核心 调查人员将继续研究临床和 HIV感染口腔表现的病理学特征 并将与项目1、2和3调查人员一起， 继续报告新的特征并探索其病因， 发病机制和治疗反应。部分内容 核心调查人员的责任和 项目将继续记录和发布这种新的 发现，并设想和测试新的假设设想 一组令人着迷和具有挑战性的疾病。