CORE--CLINICAL AND LABORATORY

临床/实验室核心的牙科和医学临床医生 将接待所有由旧金山弗朗西斯科中心转诊的病人 队列和验证诊断。 从这些转介和其他 患者转诊的来源，他们将继续建立 特定口腔病变患者的临床队列， 分析他们对艾滋病发展的反应， 其他标志物/预测因子。 他们将获得活检和其他 项目2和项目3的研究样本来自 研究对象为特征良好的口腔病变患者。 核心人员将负责临床研究专利 记录，用于样品处理和储存， 项目2和项目3调查员的助理。 他们会弄脏的 涂片和切片、处理样本和活检组织 检验员，维护病理学和其他临床实验室 数据，进行EB病毒原位杂交， 确诊为毛状白斑。 项目2和3 将使用Core B进行透射电子显微镜检查， 电子细胞化学 临床/实验室核心 研究人员将继续研究临床和 HIV感染者口腔表现的病理学特征 并与项目1、2和3的研究人员一起， 继续报告新的特征并探索其病因， 发病机制和对治疗的反应。 的一部分 研究人员在核心和 项目将继续记录和出版这些新的 研究结果，并构思和测试有关这一点的新假设 一组迷人而富有挑战性的疾病。

The dental and medical clinicians of the Clinical/Laboratory Core will see all patients referred by the San Francisco epidemiology cohorts and validate diagnoses. From these referrals and other sources of patient referrals, they will continue to build clinical cohorts of patients with specific oral lesions in order to analyze their repationship to the development of AIDS and to other markers/predictors. They will obtain biopsies and other samples for the studies in Projects 2 and 3 from well-characterized patients with the oral lesions being studied. The core staff will be responsible for clinical research pateints records, for speciment handling and storage and for getting speciments to Projects 2 and 3 investigators. They will stain smears and sections, handled samples and biopsy tissue speciments, maintain pathology and other clinical laboratory data, perform in situ hybridization for Epstein-Barr virus to confirm the diagnosis of hairy leukoplakia. Projects 2 and 3 will be using Core B for transmission electron microscopy and electron cytochemistry. The Clinical/Laboratory Core investigators will continue to study the clinical and pathological features of the oral manifestation of HIV infection and, in conjunction with Project 1, 2 and 3 investigators, will continue to report new features and to explore their etiology, pathogenesis and response to therapy. Part of the responsibilities of the investigators in the Cores and the Projects will be to continue to document and publish such new findings and to conceive and test new hypotheses concening this fascinating and challenging group of diseases.