A pharmacological approach to define the contribution of Nav1.7 to pain pathways

定义 Nav1.7 对疼痛通路贡献的药理学方法

• 批准号: nhmrc : 1102267
• 负责人: A/Pr Mehdi Mobli
• 金额: $ 34.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacological-approach-define-pain-pathways/662595
• 关键词: pharmacological; approach; define; contribution; Nav1.7

Chronic pain is a debilitating condition that affects the life of one in five Australians and has significant socioeconomic impact. Currently available pain killers often do not work, or have intolerable side effects. We have discovered the most selective blocker for a specific type of sodium channel that is a known pain target and will use this novel molecule to gain insight into the mechanisms of pain and to develop new pain killers.

慢性疼痛是一种使人衰弱的疾病，影响五分之一澳大利亚人的生活，并具有重大的社会经济影响。目前可用的止痛药往往不起作用，或有无法忍受的副作用。我们已经发现了一种特定类型的钠通道的最具选择性的阻滞剂，这是一种已知的疼痛靶点，并将使用这种新型分子来深入了解疼痛的机制并开发新的止痛药。