Rational development of novel analgesics for the treatment of chronic pain

慢性疼痛是一个主要的全球健康问题，目前影响着300多万澳大利亚人。治疗慢性疼痛的药物很少，而且大多数都有明显的副作用。缺乏一种叫做Nav1.7的特殊离子通道的人对疼痛完全不敏感，但其他方面都是正常的。因此，阻断这一通道似乎是缓解疼痛的理想途径。本项目旨在生产可作为慢性疼痛镇痛药的选择性Nav1.7阻滞剂。

Chronic pain is a major global health problem that currently affects over three million Australians. There are few drugs available for treatment of chronic pain and most have significant side-effects. Individuals lacking a particular type of ion channel known as Nav1.7 are completely insensitive to pain, but are otherwise normal. Block of this channel therefore appears to be an ideal avenue for pain relief. This project aims to produce selective Nav1.7 blockers that can be used as analgesics for treating chronic pain.