Rational development of novel analgesics for the treatment of chronic pain

合理开发治疗慢性疼痛的新型镇痛药

• 批准号: nhmrc : 1034958
• 负责人: A/Pr Mehdi Mobli
• 金额: $ 39.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rational-development-novel-chronic-pain/110943
• 关键词: Rational; development; novel; analgesics; treatment

Chronic pain is a major global health problem that currently affects over three million Australians. There are few drugs available for treatment of chronic pain and most have significant side-effects. Individuals lacking a particular type of ion channel known as Nav1.7 are completely insensitive to pain, but are otherwise normal. Block of this channel therefore appears to be an ideal avenue for pain relief. This project aims to produce selective Nav1.7 blockers that can be used as analgesics for treating chronic pain.

慢性疼痛是一个主要的全球健康问题，目前影响着300多万澳大利亚人。治疗慢性疼痛的药物很少，而且大多数都有显著的副作用。缺乏一种特殊类型的离子通道Nav1.7的人对疼痛完全不敏感，但在其他方面是正常的。因此，阻断这一通道似乎是缓解疼痛的理想途径。该项目旨在生产选择性的Nav1.7阻滞剂，可用作治疗慢性疼痛的镇痛剂。