Early diagnosis and intervention of osteoporosis using nanovibrational stimulation

利用纳米振动刺激进行骨质疏松症的早期诊断和干预

• 批准号: ST/S000968/1
• 负责人: Stuart Reid
• 金额: $ 43.82万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FS000968%2F1
• 关键词: Early; diagnosis; intervention; osteoporosis; using

Osteoporosis is a disease of the bone which affects 3M people in the UK, is associated with 300,000 fractures per year, and costs the NHS £1.9B/yr (figures provided by the National Osteoporosis Society, 2015). Current medical practice is to diagnose osteoporosis and provide pharmacological treatment only after a fragility fracture has occurred. This project seeks to revolutionise treatment through a drug-free, proactive management, through use of precision nanovibrational stimulation applied via bone conduction (similar to bone conduction headphones). Nanovibrational stimulation has recently been shown to produce osteoblasts (bone building cells) in the lab from mesenchymal stem cells (MSCs - adult stem cells found in the bone and elsewhere in the human body). This was the first time that osteogenesis (promotion of bone) has been observed in MSCs without the requirement for drugs and/or complex engineered scaffolds. Since osteoporosis has been linked to insufficient osteogenesis in MSCs, nanovibrational stimulation could provide a breakthrough route to decrease the onset, or perhaps even reverse the effects, of osteoporosis. In order to evaluate this in a timely manner, this project will study disuse-related osteoporosis (due to spinal injury) since this provides a time-accelerated model for testing interventions. The academic team will work alongside the clinicians within the Scottish Centre for Innovation in Spinal Cord Injury (SCISCI) in the Queen Elizabeth National Spinal Injuries Unit and conduct the first trials in nanovibrational stimulation for proactive treatment of osteoporosis.

骨质疏松症是一种影响英国300万人的骨骼疾病，每年与300,000个断裂有关，而NHS£1.9b/yr的费用（由国家骨质疏松症协会提供的数字，2015年）。当前的医学实践是诊断骨质疏松症，仅在发生脆性骨折发生后提供药物治疗。该项目试图通过使用通过骨传导应用的精确纳米振动刺激（类似于骨传导耳机），通过无药，积极主动的管理来彻底改变治疗。最近已显示纳米振动刺激可通过间充质干细胞（MSC-在人体中和人体其他地方发现的成年干细胞）在实验室中产生成骨细胞（骨骼建筑细胞）。这是第一次在MSC中观察到不需要药物和/或复杂的工程支架的成骨（促进骨骼）。由于骨质疏松症与MSC中的骨生成不足有关，因此纳米振动刺激可以提供突破性的途径，以减少骨质疏松症的发作，甚至可以逆转造成影响。为了及时评估这一点，该项目将研究与用途相关的骨质疏松症（由于脊柱损伤），因为这为测试干预措施提供了时间加速模型。学术团队将与伊丽莎白女王国家脊柱伤害部门的苏格兰创新中心（SCISCI）一起在苏格兰创新中心的临床医生一起工作，并进行纳米振动刺激的首次试验，以主动治疗骨质疏松症。

项目成果

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury

• DOI: 10.1101/2024.02.12.578222
• 发表时间: 2024-02
• 期刊: bioRxiv
• 作者: Jonathan A. Williams;P. Campsie;Richard Gibson;Olivia Johnson-Love;Anna S. Werner;M. Sprott;Ryan Meechan;Carmen Huesa;J. Windmill;Mariel Purcell;Sylvie Coupaud;Matthew J Dalby;Peter G. Childs;John S. Riddell;S. Reid