Early diagnosis and intervention of osteoporosis using nanovibrational stimulation

利用纳米振动刺激进行骨质疏松症的早期诊断和干预

• 批准号: ST/S000968/1
• 负责人: Stuart Reid
• 金额: $ 43.82万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FS000968%2F1
• 关键词: Early; diagnosis; intervention; osteoporosis; using

Osteoporosis is a disease of the bone which affects 3M people in the UK, is associated with 300,000 fractures per year, and costs the NHS £1.9B/yr (figures provided by the National Osteoporosis Society, 2015). Current medical practice is to diagnose osteoporosis and provide pharmacological treatment only after a fragility fracture has occurred. This project seeks to revolutionise treatment through a drug-free, proactive management, through use of precision nanovibrational stimulation applied via bone conduction (similar to bone conduction headphones). Nanovibrational stimulation has recently been shown to produce osteoblasts (bone building cells) in the lab from mesenchymal stem cells (MSCs - adult stem cells found in the bone and elsewhere in the human body). This was the first time that osteogenesis (promotion of bone) has been observed in MSCs without the requirement for drugs and/or complex engineered scaffolds. Since osteoporosis has been linked to insufficient osteogenesis in MSCs, nanovibrational stimulation could provide a breakthrough route to decrease the onset, or perhaps even reverse the effects, of osteoporosis. In order to evaluate this in a timely manner, this project will study disuse-related osteoporosis (due to spinal injury) since this provides a time-accelerated model for testing interventions. The academic team will work alongside the clinicians within the Scottish Centre for Innovation in Spinal Cord Injury (SCISCI) in the Queen Elizabeth National Spinal Injuries Unit and conduct the first trials in nanovibrational stimulation for proactive treatment of osteoporosis.

骨质疏松症是一种影响英国300万人的骨骼疾病，每年与30万骨折有关，每年花费NHS GB 1.9亿英镑(由国家骨质疏松症协会提供的数据，2015)。目前的医学实践是，只有在脆性骨折发生后才能诊断骨质疏松症并提供药物治疗。该项目寻求通过使用通过骨传导(类似于骨传导耳机)施加的精确纳米振动刺激，通过无药物、积极主动的管理来革命性地治疗。最近，纳米振动刺激在实验室中被证明可以从间充质干细胞(MSCs--存在于骨骼和人体其他部位的成骨干细胞)中产生成骨细胞(骨构建细胞)。这是首次在不需要药物和/或复杂工程支架的情况下在MSCs中观察到成骨(促进骨)。由于骨质疏松症与骨髓间充质干细胞成骨不足有关，纳米振动刺激可以提供一个突破性的途径来减少骨质疏松症的发生，甚至逆转其影响。为了及时评估这一点，本项目将研究与废用相关的骨质疏松症(由于脊柱损伤)，因为这为测试干预措施提供了一个时间加速模型。该学术团队将与伊丽莎白女王国家脊柱损伤单位苏格兰脊髓损伤创新中心(SCISCI)的临床医生一起工作，并进行用于主动治疗骨质疏松症的纳米振动刺激的首批试验。

项目成果

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury

• DOI: 10.1101/2024.02.12.578222
• 发表时间: 2024-02
• 期刊: bioRxiv
• 作者: Jonathan A. Williams;P. Campsie;Richard Gibson;Olivia Johnson-Love;Anna S. Werner;M. Sprott;Ryan Meechan;Carmen Huesa;J. Windmill;Mariel Purcell;Sylvie Coupaud;Matthew J Dalby;Peter G. Childs;John S. Riddell;S. Reid