CORE--GHC POPULATION AND SURVEILLANCE

此核心的总体目标是支持个别项目和 通过确定和招募患者来实现总体目标 通过收集胃肠道来参与计划项目研究 从病例中提取的癌症组织发生在大约 40万注册人数，增强计划项目能力 研究人员将对结肠和胰腺进行纵向研究 癌症。通过健康研究中心，GHC人口核心 将促进获得医疗保健提供系统，该系统具有独特的 作为翻译研究环境的优势，包括大型 明确的患者群体和丰富的信息系统； 已建立的癌症筛查计划与风险因素和 病理结果；以及在设计、实施和分析方面的经验 癌症预防、控制的干预和观察性研究 和治疗。 GHC人口核心的具体目标是：1)确定和 收集慢性胰腺炎患者的胰腺标本 癌症和结肠癌为拟议项目1和4；2)招聘 接受结肠镜检查并收集危险因素数据的患者，粪便和 血液样本和活检结果，以及纵向的组织样本 结肠癌风险和发展的研究；以及4)建立 监测胃肠道癌症变化的监测系统 在我们定义的人群中的发病率、发病率和死亡率。GHC Popular Core将建立和维护一个追溯登记， 9800多名接受手术的患者的相关病理结果 1991年至1996年的结肠镜检查，并将增加危险因素数据 预计将有4800名患者在项目期间接受结肠镜检查 句号。 团体健康合作社(GHC)是一个工作人员模式的管理型护理组织 它为华盛顿西部普吉特海湾的40多万名注册人员提供服务 区域。GHC人口核心将在GHC中心内运行 健康研究，一个致力于开展 促进公共领域的科学知识的研究和 GHC的医疗保健质量。

The Overall goal of this Core is to support individual projects and overall objectives by identifying and recruiting patients for participation in Program Project Studies, by collecting gastrointestinal cancer tissues from cases that arise in a population of approximately 400,000 enrollees, and by enhancing the ability of Program Project investigators to conduct longitudinal studies in colon and pancreas cancer. Through the Center for Health Studies, the GHC Population Core will facilitate access to a health care delivery system that has distinct advantages as a setting for translational research that include a large defined patient population and a rich array of information systems; established programs in cancer screening with linkage to risk factors and pathologic outcomes; and experience in the design, conduct, and analysis of intervention and observational studies of cancer prevention, control and treatment. The specific aims of the GHC Population Core are: 1) To identify and collect specimens from patients with chronic pancreatitis, pancreatic cancer, and colon cancer for proposed projects 1 and 4; 2) To recruit patients undergoing colonoscopy and collect risk factor data, fecal and blood samples, and biopsy results, and tissue specimens for longitudinal studies of colon cancer risk and development; and 4) To establish a surveillance system to monitor changes in gastrointestinal cancer incidence, morbidity, and mortality in our defined population. The GHC Population Core will build and maintain a retrospective registry with linked pathology results of more than 9800 patients who underwent colonoscopy between 1991 and 1996 and will add risk factor data for the anticipated 4800 patients who will be colonoscopied during the project period. Group Health Cooperative (GHC) is a staff-model managed care organization that serves over 400,000 enrollees in the western Washington Puget Sound region. The GHC Population Core will operate within the GHC Center for Health Studies, a research organization dedicated to the conduct of studies that contribute to scientific knowledge in the public domain and to the quality of health care at GHC.