CORE--SYNTHETIC CHMEMISTRY

核心--合成化学

• 批准号: 6300648
• 负责人: MATTHEW D SHAIR
• 金额: $ 48.07万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-10 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300648
• 关键词: antineoplastics; biomedical automation; biomedical facility; chemical registry /resource; chemical structure; chemical synthesis; drug screening /evaluation; nanotechnology

We will establish a Synthetic Chemistry Core (SCC) facility that will synthesize small molecules and reagents essential for the work of Projects 1, 2, and 3. The SCC will synthesize reagents necessary for the creation of the small molecule libraries described in Project 1, including monomers, tags, and templates. Automated synthesizers will be introducer over time to increase monomer diversity and the speed with which new monomers can be generated. The SCC will also be responsible for resynthesizing libraries as they are consumed in the assays described in Projects 2 and 3. The SCC will organize the monomers that are synthesized for Project 1, and maintain a chemical stock facility for use by the entire Institute of Chemistry and Cell Biology. Analytical instrumentation used for the structural analysis of small molecules will be located predominantly within the SCC, and will be managed and maintained by members of the SCC. The SCC will be responsible for decoding the tags that are used to encode the synthesis strategies employed a library construction. The SCC will receive synthesis beads that have been assayed by Projects 2 and 3 and found to have biological activity. Once the tag is decoded, the SCC will resynthesize the appropriate small molecule, and return it to investigators in Projects 2 and 3. Once the activity of the small molecule is reconfirmed, the SCC will design a series of structural derivatives of the small molecule to enable structure-activity studies to be performed. The most active small molecule will then be synthesized in larger quantity by the SCC, for testing in additional biological assays and to send the compound to our collaborators for analysis. The Administrator Core A will coordinate compound shipments and communications will collaborators, and will provide administrative support and financial oversight to the SCC. The efforts of the SCC will be overseen by Prof. Matthew Shair, also a co- investigator of Project 1. The SCC will be managed by a chemist with experience in the are of split-pool synthesis, monomer synthesis, and encoding strategies. This individual will be responsible for managing the daily activities of the SCC, and will be a member of the ICCB steering committee.

我们将建立一个合成化学核心（SCC）设施 合成项目工作必不可少的小分子和试剂 1、2和3。SCC将合成创建所需的试剂 项目1中描述的小分子库，包括 单体，标签和模板。自动合成器将成为介绍器 随着时间的流逝，增加单体多样性和新的速度 可以生成单体。 SCC也将负责 重新合成图书馆在所描述的测定中消耗的图书馆 项目2和3。SCC将组织合成的单体 对于项目1，并维护化学库存设施供 整个化学与细胞生物学研究所。 用于小型结构分析的分析仪器 分子将主要位于SCC内，将是 由SCC的成员管理和维护。 SCC将负责 用于解码用于编码合成策略的标签 采用了图书馆建筑。 SCC将收到合成珠 已被项目2和3分析，发现具有生物学 活动。标签解码后，SCC将重新合成 适当的小分子，并将其归还项目2的调查人员 3。一旦重新确定了小分子的活性，SCC 将设计一系列小分子的结构衍生物 能够进行结构活性研究。最活跃的小 然后，分子将由SCC以更大的量合成，因为 在其他生物学测定中进行测试，并将化合物发送给我们 分析的合作者。管理员核心A将坐标 复合货物和通讯将合作，并将提供 对SCC的行政支持和财务监督。 SCC的努力将由Matthew Shair教授进行监督，Matthew Shair教授也是 项目1的研究人员。SCC将由化学家管理 具有分裂池合成，单体合成和 编码策略。这个人将负责管理 SCC的日常活动，并将成为ICCB转向的成员 委员会。