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CYTOSINE ARABINOSIDE FOR MULTIFOCAL LEUKOENCEPHALOPATHY IN HIV INFECTION

CYTOSINE ARABINOSIDE FOR MULTIFOCAL LEUKOENCEPHALOPATHY IN HIV INFECTION
阿糖胞苷治疗 HIV 感染引起的多灶性白质脑病
批准号：
6302836
负责人：
COLIN D HALL
金额：
$27.36万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-05-01 至 2001-04-30
来源：
https://reporter.nih.gov/project-details/6302836
关键词：
2'3' dideoxycytidine 2'3' dideoxyinosine AIDS therapy HIV infections antiviral agents colony stimulating factor cytosine arabinoside human subject human therapy evaluation nervous system disorder chemotherapy neuropsychological tests progressive multifocal leukoencephalopathy zidovudine

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中文摘要
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英文摘要
This Project will evaluate the effectiveness of cytosine arabinoside for treatment of biopsy proven progressive multifocal leukoencephalopathy in subjects with human immunodeficiency virus infection. A three arm study comparing best possible anti-retroviral therapy with either intravenous ARA-C therapy administered through an Ommaya reservoir. Twenty patients will be randomized to each arm of the study. The primary endpoint is death within 24 weeks. Secondary end points will be neurologic deterioration as indicated by neurologic examination and deterioration in Karnofsky Performance Scores.
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NEUROLOGICAL RESPONSE TO HAART
CEREBROSPINAL FLUID HIV-1 AND COGNITIVE FUNCTION IN PATIENTS RECEIVING THERAPY
NEUROLOGICAL RESPONSE TO HAART
NEUROLOGICAL RESPONSE TO HAART
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