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Sub voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging (small pixel camera)

用于低剂量分子乳腺成像的碲化镉锌探测器中的亚体素位置识别（小像素相机）

基本信息

批准号：
ST/T003308/1
负责人：
Laura Joanne Harkness-Brennan
金额：
$ 4.59万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=ST%2FT003308%2F1
关键词：
Sub voxel position identification Cadmium

项目摘要

The funded knowledge exchange project seeks to develop an optimised Cadmium Zinc Telluride (CZT) system for low dose molecular breast imaging (MBI). Breast cancer is the most common type of cancer in the UK, with 1 in 8 women developing the disease. Approximately 50% of women of screening age have mammographically dense breasts but conventional X-ray mammography has reduced diagnostic performance for these patients. This limitation can be overcome by using MBI, a technique in which a molecular tracer selectively targets malignant breast tissue to provide high-resolution functional images. Earlier diagnosis and more accurate staging of the disease using optimised MBI systems will potentially lead to better patient outcomes and reduced mortality rates. The proposed research will improve the imaging performance of MBI, which will increase the probability of detecting lesions in the breast. This will be based on exploiting our knowledge of how radiation interacts in the imaging system. The additional research to be undertaken with the requested equipment in this new call will be to explore the possibility of using the techniques to enhance imaging performance for medical applications such as diagnosis of Alzheimer's and cardiac disease.

受资助的知识交流项目旨在开发用于低剂量分子乳腺成像（MBI）的优化碲锌镉（CZT）系统。乳腺癌是英国最常见的癌症类型，每8名女性中就有1名患有这种疾病。大约50%的筛查年龄的妇女具有乳房X线摄影致密的乳房，但传统的X线乳房X线摄影降低了对这些患者的诊断性能。这种局限性可以通过使用MBI来克服，MBI是一种分子示踪剂选择性地靶向恶性乳腺组织以提供高分辨率功能图像的技术。使用优化的MBI系统对疾病进行更早的诊断和更准确的分期将可能导致更好的患者结局和降低死亡率。拟议的研究将提高MBI的成像性能，这将增加检测乳腺病变的概率。这将是基于利用我们的知识，辐射如何在成像系统中相互作用。在这项新的呼叫中，将对所要求的设备进行的额外研究将是探索使用这些技术来增强成像性能的可能性，以用于诊断阿尔茨海默氏症和心脏病等医疗应用。