RANDALL'S PLAQUES--RELATIONSHIP TO NEPHROLITHIASIS

兰德尔斑块——与肾结石的关系

基本信息

  • 批准号:
    6349617
  • 负责人:
  • 金额:
    $ 10.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-08-01 至 2005-06-30
  • 项目状态:
    已结题

项目摘要

In the clinical setting, it is a common observation that all fixed renal pelvic stones are adherent to the papilla (either the distal end of the ducts of Bellini, the renal papilla surface, or, less often, to the forniceal region). Stones are new found attached directly to the transitional epithelium of the papilla without ulceration and/or plaque. Once the stone dislodged from its' point of attachment, a site of eruption is noted in the transitional epithelium associated with the stone and that this site of eruption has, as its foundation or base, a plaque, termed a Randall's plaque after discovered. A clinical spectrum of papillary plaques is seen, from small subepithelial plaques to large, eroded plaques with a common association of attached calcium oxalate stones. The majority of the plaque area appears to be local beneath the transitional epithelium (subepithelial). Histologic examination of the affected papilla shows a region plaque extending into the interstitium of the papilla with additional regions of crystal deposition involving all tissues the papillary tip. The process by which a plaque forms is presently not known; however, it has been hypothesized (Anderson-Carr-Randall progression of renal calculus formation) that calcium deposits begin within the tissues of the papilla, which may migrate to a subepithelial position, forming Randall's plaques. The uniqueness of the experimental design of this project is that we will undertake this study in kidneys of well-characterized human stone formers using the technical advances that have occurred in endoscopic equipment and percutaneous surgical techniques. Such approach has not been previously used to study the pathogenesis of uroliathiasis. Tissue samples will be collected from all regions of the kidney and analyzed using crystallography, Fourier transform infrared microscopy and spectroscopy quantitatively energy and wavelength dispersive analysis, light; transmission and scanning electron microscopy. The morphological/analytical data will then be correlated with physiologic data (serum and urine studies) collected from patients. Within the construct of a cooperative program project, we plan to determine what are the important a substantive steps that lead to pathologic formation of uroliathiasis. The other projects will address urinary metabolic factors and crystal inhibitors (Project 1), hypercalciuria in an animal model (Project 3), vitamin D physiology (Project 4) and crystal-cell interactions, growth and inhibitions (Project 5).
在临床环境中,常见的观察结果是所有固定的肾盂结石都粘附在乳头上(贝里尼管的远端、肾乳头表面,或者较少见的是穹窿区域)。新发现的结石直接附着在乳头的移行上皮上,没有溃疡和/或斑块。一旦结石从其附着点脱落,就会在与结石相关的过渡上皮中注意到一个喷发部位,并且该喷发部位有一个斑块作为其基础或基底,被发现后称为兰德尔斑块。可以看到乳头状斑块的临床范围,从小的上皮下斑块到大的、通常与附着的草酸钙结石相关的侵蚀斑块。大部分斑块区域似乎位于移行上皮(上皮下)下方。受影响的乳头的组织学检查显示区域斑块延伸到乳头的间质中,并且晶体沉积的附加区域涉及乳头尖端的所有组织。目前尚不清楚斑块形成的过程。然而,据推测(肾结石形成的Anderson-Carr-Randall进展),钙沉积开始于乳头组织内,可能迁移到上皮下位置,形成兰德尔斑块。该项目实验设计的独特性在于,我们将利用内窥镜设备和经皮手术技术的技术进步,在特征明确的人类结石形成者的肾脏中进行这项研究。这种方法以前尚未用于研究尿路结石的发病机制。将从肾脏的所有区域收集组织样本,并使用晶体学、傅里叶变换红外显微镜和光谱定量能量和波长色散分析、光进行分析;透射和扫描电子显微镜。然后,形态学/分析数据将与从患者收集的生理数据(血清和尿液研究)相关联。在合作项目的构建中,我们计划确定导致尿路结石病理形成的重要和实质性步骤。其他项目将涉及尿代谢因素和晶体抑制剂(项目 1)、动物模型中的高钙尿症(项目 3)、维生素 D 生理学(项目 4)以及晶体细胞相互作用、生长和抑制(项目 5)。

项目成果

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JAMES E LINGEMAN其他文献

JAMES E LINGEMAN的其他文献

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{{ truncateString('JAMES E LINGEMAN', 18)}}的其他基金

RANDALL'S PLAQUE: PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块:发病机制及其与肾结石的关系
  • 批准号:
    8231179
  • 财政年份:
    2011
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES-- PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——发病机制及其与肾结石的关系
  • 批准号:
    7490027
  • 财政年份:
    2007
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES-- PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——发病机制及其与肾结石的关系
  • 批准号:
    7311585
  • 财政年份:
    2006
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES-- PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——发病机制及其与肾结石的关系
  • 批准号:
    6898581
  • 财政年份:
    2005
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES--RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——与肾结石的关系
  • 批准号:
    6600906
  • 财政年份:
    2002
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES--RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——与肾结石的关系
  • 批准号:
    6502962
  • 财政年份:
    2001
  • 资助金额:
    $ 10.78万
  • 项目类别:
Plaques and Plugs: Pathogenesis and Relationship to Nephrolithiasis
斑块和栓塞:发病机制及其与肾结石的关系
  • 批准号:
    10246877
  • 财政年份:
    2000
  • 资助金额:
    $ 10.78万
  • 项目类别:
Plaques and Plugs: Pathogenesis and Relationship to Nephrolithiasis
斑块和栓塞:发病机制及其与肾结石的关系
  • 批准号:
    9359532
  • 财政年份:
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUES-- PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块——发病机制及其与肾结石的关系
  • 批准号:
    7932915
  • 财政年份:
  • 资助金额:
    $ 10.78万
  • 项目类别:
RANDALL'S PLAQUE: PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS
兰德尔斑块:发病机制及其与肾结石的关系
  • 批准号:
    8541652
  • 财政年份:
  • 资助金额:
    $ 10.78万
  • 项目类别:

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