RANDALL'S PLAQUES-- PATHOGENESIS AND RELATIONSHIP TO NEPHROLITHIASIS

兰德尔斑块——发病机制及其与肾结石的关系

• 批准号: 7490027
• 负责人: JAMES E LINGEMAN
• 金额: $ 7.22万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490027
• 关键词: Anatomy; Apatites; Appearance; Area; Bariatrics; Biopsy; Bowman' s space; Calcium Oxalate; Calculi; Characteristics; Clinical; Crystal Formation; Cystine; Deposition; Development; Diverticulum; Endoscopy; Event; Excision; Histologic; Hydroxyapatites; Ileostomy; Imagery; Individual; Intestinal Bypasses; Invasive; Kidney; Kidney Calculi; Liquid substance; Maps; Measurable; Metabolic; Modeling; Nephrolithiasis; Obstruction; Papillary; Pathogenesis; Patients; Pattern; Phenotype; Physiological; Protocols documentation; Purpose; Recording of previous events; Renal pelvis; Risk Factors; Role; Science; Site; Spiral Computed Tomography; Standards of Weights and Measures; System; Techniques; Technology; Tissues; Ureteropelvic junction obstruction; Uric Acid; Urinary Calculi; Urine; Work; X-Ray Computed Tomography; base; brushite; clinically significant; detector; size; urinary

The sequence of events culminating in a renal calculus of clinically significant size remains to be established. Our work with thorough clinical, endoscopic, metabolic, and histologic examination of stone formers (SF) suggests that specific physiologic events in the kidney result in characteristic patterns of crystal deposition and eventual stones. Aim 1 will extend our work, which began with the confirmation and elaboration of the work of Randall in common calcium oxalate SF and is extending to include other crystal deposits and stone phenotypes. In Aim 2 we hypothesize that rigorous examination of common calcium oxalate SF undergoing endoscopic stone removal will demonstrate either stone attached to plaque or evidence of plaque in any non-attached stones. As with Aim 1, the protocol of Aim 2 will be extended to other stone phenotypes. With the development of multi-detector CT technology, non-invasive visualization of Randall's plaque (RP) is now possible. Using our now well established endoscopic mapping techniques as a standard, Aim 3 will attempt to define and quantitate CT plaque characteristics and will investigate radiographic criteria for distinguishing RP from stone. Finally, Aim 4 will explore the relationship of urinary stasis to stone formation, a topic that heretofore has not been subjected to rigorous science. Two models (calyceal diverticula, ureteropelvic junction obstruction) will be utilized in this Aim.

最终形成具有临床意义的肾结石的一系列事件仍有待确定。我们对结石患者进行了全面的临床、内窥镜、代谢和组织学检查，结果表明肾脏中的特定生理事件导致晶体沉积和最终结石的特征性模式。Aim 1将扩展我们的工作，从确认和阐述Randall在普通草酸钙SF中的工作开始，并扩展到包括其他晶体沉积和石头表型。