Treatment of cystic fibrosis with soy derived isoflavones

用大豆异黄酮治疗囊性纤维化

• 批准号: 6359976
• 负责人: Gavin R Graff
• 金额: $ 6.54万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359976
• 关键词: aerosols; alternative medicine; chloride channels; clinical research; cystic fibrosis; diet; dosage; drug adverse effect; drug screening /evaluation; endocrine disorder chemotherapy; flavones; genistein; high performance liquid chromatography; human subject; human therapy evaluation; membrane potentials; nutrition related tag; pharmacokinetics; soybeans

Description: The investigators propose to develop a aerosol delivery system containing genistein and a b-agonist (broncho-dilator) for the treatment of cystic fibrosis (CF). Preliminary studies have shown that genistein interacts with the CF transmembrane conductance regulator which is defective in patients with CF as a result of a specific mutation. Genistein raises the bioelectric potential differences (PD) across the nasal membrane and increases chloride transport. These investigators are directed at developing an aerosol by evaluating the dose and pharmacokinetics of genistein in regard to altering PD, performing a repetitive dose experiment with the aerosol, and finally performing safety studies with this aerosol. A final study will investigate the efficacy of using oral genistein supplements to alter the nasal membrane PD.

产品描述：研究人员建议开发一种含有染料木黄酮和b-激动剂（支气管扩张剂）的气雾剂递送系统，用于治疗囊性纤维化（CF）。初步研究表明，染料木黄酮与CF跨膜传导调节因子相互作用，CF跨膜传导调节因子在CF患者中由于特定突变而有缺陷。染料木黄酮提高跨鼻膜的生物电势差（PD）并增加氯离子转运。这些研究人员致力于通过评价染料木黄酮改变PD的剂量和药代动力学来开发气雾剂，用气雾剂进行重复剂量实验，最后用该气雾剂进行安全性研究。最后一项研究将调查使用口服染料木黄酮补充剂改变鼻膜PD的疗效。