CORE--AMBIENT PARTICLE EXPOSURE AND CHARACTERIZATION FACILITY

核心——环境颗粒暴露和表征设施

• 批准号: 6301544
• 负责人: PETROS KOUTRAKIS
• 金额: $ 31.6万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301544
• 关键词: air pollution; air sampling /monitoring; bioengineering /biomedical engineering; biomedical equipment; biomedical equipment resource; biomedical facility; particle

This Core will be responsible for the generation and characterization of the ambient aerosols to conduct inhalation exposures. The ambient particle concentrator system that we have recently developed will be used to generate ambient aerosols at desirable levels, under controlled temperature and relative humidity conditions. Using a number of continuous and time-integrated samplers the physical chemical, and biological properties of the particles supplied to the inhalation chamber will be determined. Particle mass concentration, size distribution, inorganic ions and strong acidity, trace metals, elemental carbon, as well fungal and pollen spores and endotoxin concentrations will be determined. In addition, the oxidation generating potential of particles will be measured. Furthermore, particle samples will be collected for subsequent in vitro cellular studies. Finally, gaseous air pollutant concentrations, including carbon monoxide, ammonia, nitrogen dioxide, and nitric oxide will be monitored. Depending on optional experimental conditions, ozone, nitric and nitrous acids, and sulfur dioxide concentrations will also be measured, when a diffusion denuder system is not placed upstream of the exposure chamber to remove these gases. This Core relates to the other Projects because it proviede generation and characterization of ambient aerosols for both in vivo and in vitro studies. In addition, since the core includes experts in atmopheric sciences and biostatistics, it will provide support to all projects in understanding the sources and types of particles and in relating the observed biological effects to the various measured particle attributes. Therefore, the intent of this core is not only to provide the engineering expertise and facilities for generating and characterizing the exposure atmospheres but also to integrate the exposure and health effects studies in this project. This will be of paramount importance for both the interpretation and synthesis of the collected data.

这个核心将负责生成和 进行吸入的环境气溶胶的表征 暴露。 我们现有的环境粒子集中器系统 最近开发的将用于产生环境气溶胶， 在受控温度和相对湿度下， 湿度条件。 使用多个连续和时间积分采样器， 粒子的物理化学和生物学特性 将确定供应到吸入室的量。 颗粒 质量浓度、粒径分布、无机离子和强 酸度，微量金属，元素碳，还有真菌和花粉 测定孢子和内毒素浓度。 在 此外，颗粒的氧化生成电势将是 测定了 此外，还将收集颗粒样品， 随后的体外细胞研究。 最后，气态空气污染物 浓度，包括一氧化碳、氨、氮 二氧化碳和一氧化氮将被监测。 取决于可选的 实验条件、臭氧、硝酸和亚硝酸以及硫 还将测量二氧化物浓度，当扩散 扩散管系统不放置在暴露室的上游， 清除这些气体。 这个核心与其他项目有关，因为它提供了 环境气溶胶的产生和表征 体内和体外研究。 此外，由于核心包括 大气科学和生物统计学方面的专家， 支持所有项目，以了解 粒子和相关的观察到的生物效应， 各种测量的粒子属性。 因此，这一意图 核心不仅是提供工程专业知识和设施， 用于产生和表征曝光气氛， 此外，还将暴露和健康影响研究纳入本报告， 项目 这对双方都至关重要。 对收集到的数据进行解释和综合。