CORE--PHYSIOLOGY AND BIOCHEMISTRY LABORATORY

实验室核心旨在支持五个项目， 满足他们对生化和生理测量的需求 来识别它们的中间表型。广泛的检测范围 与盐敏感性高血压有密切关系， 血管紧张素-醛固酮轴，激肽系统，血管紧张素-醛固酮轴的评估 高血压、肾灌注和钠稳态的决定因素。所有 核心中描述的技术和测定方法目前正在使用， 核心所包含的实验室，以及专业和 实验室工作人员在履行其职责时已经相互作用。的 核心结构通过规模经济节约成本， 有效的资源分配，改善质量控制， 协作 其他优点包括减少周转时间， 分析和更有效的适应新的需求出现。我们 幸运的是，该计划中的实验室核心不是一个结构， 为这个提议发明的，而是一个当前的，活跃的资源， 将能够在结构中以更高的效率运作， 由节目提供。我们也很幸运， 这里描述的协作安排再次不是 这是一个为这个建议而发明的结构，而是反映了长期以来， 持续的关系。

The laboratory core is designed to support the five projects by satisfying their needs for the biochemical and physiological measurements that identify their intermediate phenotypes. The wide range of assays provided are germane to salt-sensitive hypertension, the renin- angiotensin-aldosterone axis, the kinin system, assessment of the determinants of hypertension, renal perfusion and sodium homeostasis. All of the techniques and assays described in the core are in current use in the laboratories encompassed by the core, and the professional and laboratory active personnel already interact in filling their roles. The core structure results in cost savings through economy of scale and more efficient resource allocation, improves quality control and facilitates collaboration. Additional advantages include reduced turnaround time on assays and more efficient adaptation as new demands arise. We are fortunate in that the laboratory core in this program is not a construct invented for this proposal, but rather a current, active resource which will be able to function with far greater efficiency in the structure provided by the program. We are also fortunate that all of the collaborative arrangements described herein, once again, are not a construct invented for this proposal but rather reflect longstanding and ongoing relationships.