COCOA, POLYPHENOLS AND THE KIDNEY IN HEALTHY HUMANS

可可、多酚和健康人的肾脏

• 批准号: 7379221
• 负责人: NORMAN K HOLLENBERG
• 金额: $ 13.08万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379221
• 关键词: COCOA; POLYPHENOLS; KIDNEY; HEALTHY; HUMANS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To expose the possibility that the mechanism which polyphenol-rich cocoa influences renal hemodynamics involves activation of intrarenal nitric oxide synthase. To make that assessment, we are measuring the metabolic products of nitric oxide synthesis in urine and blood, and assessing the influence on the renal blood supply of blocking nitric oxide synthesis with L-NAME. This is an investigator initiated study.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。为了揭示富含多酚可可的机制影响肾脏血流动力学的机制涉及培养剂氮氧化物合酶的激活。为了进行该评估，我们正在测量尿液和血液中一氧化氮合成的代谢产物，并评估与L-NAME封闭一氧化氮合成的肾脏血液供应的影响。这是一项研究人员的发起研究。