COCOA, POLYPHENOLS AND THE KIDNEY IN HEALTHY HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 为了揭示富含多酚的可可影响肾脏血流动力学的机制涉及肾内一氧化氮合酶的激活的可能性。为了进行这一评估，我们正在测量尿液和血液中一氧化氮合成的代谢产物，并评估L阻断一氧化氮合成对肾脏血液供应的影响。这是一项由研究人员发起的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To expose the possibility that the mechanism which polyphenol-rich cocoa influences renal hemodynamics involves activation of intrarenal nitric oxide synthase. To make that assessment, we are measuring the metabolic products of nitric oxide synthesis in urine and blood, and assessing the influence on the renal blood supply of blocking nitric oxide synthesis with L-NAME. This is an investigator-initiated study.