Neural mechanisms of size and shape perception in somatosensory cortex

体感皮层大小和形状感知的神经机制

• 批准号: 6326017
• 负责人: STEVEN S HSIAO
• 金额: $ 19.64万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326017
• 关键词: Macaca mulatta; afferent nerve; behavioral /social science research tag; electronic recording system; fingers; form /pattern perception; hand; microelectrodes; neural information processing; orientation; proprioception /kinesthesia; psychophysics; sensory mechanism; sensory signal detection; size perception; somesthetic sensory cortex; stimulus /response; touch

Funds are requested to study the neural mechanisms underlying three- dimensional (3D) shape and size perception in somatosensory system. While the perception of local surface features is based on the activity in the mechanoreceptive afferents innervating the skin, gross object features such as shape and size are based on hand and finger position and cutaneous information from multiple points of contact with the object. Project 1 concentrates on how information is integrated from the multiple points of contact; This project (3) concentrates on the role of hand and finger position in 3D form processing. The aim is to study how information from tactile and proprioceptors within and between digits are integrated in SI and SII cortex of the awake monkey to provide information about the 3D shape and size of objects. Aim 1 is to investigate the processing of shape information by studying the integration of tactile information across adjacent digits positioned at different combinations of flexion, simulating contact with objects with varying shapes. Aim 2 is to investigate the processing of information about object size by studying how digit spread affects the responses of somatosensory neurons to local patents of stimulation. Two modes of stimulation, active and passive, will be used. In the passive mode stimuli that are or are not consistent with a single curved surface (aim 1) or stimulate an object of a specified size (aim 2) will be applied to the hand while the animal performs a tactile match-to-sample task. In the active mode, the animal actively moves it fingers to contact the stimuli that vary in curvature and size. In this manner we will study neuronal response tuning for object size and shape in various areas in the somatosensory cortex and determine and whether the tuning differs during active and passive touch.

需要资金来研究体感系统中三维形状和大小感知的神经机制。虽然局部表面特征的感知是基于支配皮肤的机械感受传入神经的活动，但物体的总体特征（如形状和大小）是基于手和手指的位置以及来自与物体接触的多个点的皮肤信息。项目1侧重于如何从多个接触点集成信息；本项目(3)主要研究手和手指位置在3D表单处理中的作用。目的是研究来自手指内部和之间的触觉和本体感受器的信息如何在清醒的猴子的SI和SII皮层中整合，以提供关于物体的三维形状和大小的信息。目的1是通过研究不同屈曲组合下相邻手指的触觉信息整合，模拟与不同形状物体的接触，来研究形状信息的处理。目的二是通过研究手指扩展如何影响体感觉神经元对局部刺激的反应来研究物体大小信息的加工。将采用主动和被动两种刺激模式。在被动模式下，当动物执行触觉匹配样本任务时，将对手部施加与单一曲面（目标1）或不与单一曲面（目标2）一致的刺激或刺激特定尺寸的物体（目标2）。在主动模式下，动物主动移动它的手指来接触曲率和大小不同的刺激。通过这种方式，我们将研究体感皮层中不同区域对物体大小和形状的神经元反应调节，并确定在主动和被动触摸过程中调节是否不同。