IMPROV OF RES FACIL: AGING, ALZHEIMER

改善RES FACIL：衰老、阿尔茨海默病

• 批准号: 6794361
• 负责人: PETER LANGE
• 金额: $ 40万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794361
• 关键词: Alzheimer's disease; aging; animal colony; biomedical facility; brain; building /facility design /renovation; laboratory mouse; laboratory rat; neurogenetics; neuropsychology

DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to create a unique, state-of-the-art facility for behavioral neuroscience and genomics research, to be called the Center for Behavioral Neuroscience and Genomics, within Duke's Center for Models of Human Disease. This facility will unite behavioral neuroscientists with cell and molecular biologists to investigate the brain and behavioral mechanisms underlying cognitive and motivational systems. Specific Aims: 1) bring behavioral neuroscientists in close proximity to cell biologists and geneticists so that they can join forces to seek molecular mechanisms underlying adaptive behaviors; 2) provide a facility with modular units that are easily adaptable to current and future research needs; 3) offer common research resources that can be readily used by all researchers in the facility and by collaborators; 4) create common infrastructure resources so that space is used maximally and efficiently; 5) provide expanded animal housing - 1,000 rat cages, 100 mouse rages, and 100 other types (e.g., birds, fish) - that will more than double current capacity, markedly enhancing long-term animal housing; and 6) establish a clear separation of animal research and public space so that security, noise, and air-handling can be tightly controlled and monitored, which is essential for high quality behavioral research.

描述（由申请人提供）：拟议项目的长期目标是在杜克大学人类疾病模型中心内建立一个独特的、最先进的行为神经科学和基因组学研究设施，称为行为神经科学和基因组学中心。该设施将把行为神经科学家与细胞和分子生物学家联合起来，研究认知和动机系统背后的大脑和行为机制。具体目标：1)将行为神经科学家与细胞生物学家和遗传学家紧密联系起来，使他们能够联合起来寻求适应行为的分子机制；2)提供易于适应当前和未来研究需求的模块化单元设施；3)提供可供设施内所有研究人员和合作者随时使用的共同研究资源；4)创造共同的基础设施资源，使空间得到最大限度和有效的利用；5)提供扩大的动物住房——1000个鼠笼、100个鼠笼和100个其他类型（如鸟、鱼）——这将使目前的容量增加一倍以上，显著改善长期的动物住房；6)建立动物研究与公共空间的明确分离，以便严格控制和监测安全，噪音和空气处理，这对高质量的行为研究至关重要。