RES FACIL CONST: GENETICS & EVOLUTION: MYCROBOTRYUM AS A MODEL

描述(申请人提供)：这项申请的长期目标是加强分子和细胞生物学方面的生物医学研究能力，在生物系和UVA。具体目标是翻新吉尔默大厅一楼，以提供以下设施：1)三个现代分子和细胞生物学研究实验室；2)供使用这些实验室和其他细胞和分子生物学实验室的支持区域和会议室；以及3)研究和支持空间，将现有研究实验室目前分散的人员和设备集中在一个地点。在生物系的内部和外部审查中，形态发生被确定为重点的主要举措。生物系在发育遗传学、发育生物学和成像技术方面实力雄厚，特别是考虑到附近医学院的优势互补，随着基因组计划的到来，新的成像和生物物理方法的发展，以及干细胞研究中医学应用的新可能性，形态发生是一个令人兴奋的进步领域。为了加强现有的优势和利用这些新的发展，生物系必须加强其细胞生物学方法的形态发生，特别是在细胞骨架、分子马达、细胞黏附、细胞极性、RNA和蛋白质的运输和定位、细胞黏附和细胞迁移等领域。拟议的翻修将包括为这些地区的两个新的研究学院提供新的实验室空间，并为这些实验室和整个Gilmer Hall的现有实验室提供支持区域，从而加强生物学和大学其他地方的生物医学研究计划。

DESCRIPTION (provided by applicant): The long-term objective of this application is to enhance the biomedical research capabilities in molecular and cellular biology in the Department of Biology and the UVA. Specific aims are to renovate on the ground floor of Gilmer Hall to provide the following: 1) three modern molecular and cellular biology research laboratories; 2) support areas and conference rooms for use of these and other cell and molecular biology laboratories; and 3) research and support space to consolidate at one site the currently dispersed personnel and equipment of an existing research laboratory. Morphogenesis was identified in an internal and external review of the Department of Biology as the major initiative for emphasis. The Biology Department is strong in developmental genetics, developmental biology, and imaging technology, especially in light of complementing strengths in the School of Medicine nearby, and morphogenesis is an area of exciting progress with the advent of the genome projects, development of new imaging and biophysical methods, and new possibilities for medical applications in stem cell research. To enhance existing strengths and take advantage of these new developments, the Department of Biology must strengthen its cell biological approaches to morphogenesis, specifically in such areas as the cytoskeleton, molecular motors, cell adhesion, cell polarity, transport and localization of RNA and proteins, cell adhesion, and cell migration. The proposed renovations will include new laboratory space for two new research faculties in these areas and provide support areas for these and existing laboratories throughout Gilmer Hall, thus enhancing biomedical research programs in Biology and elsewhere at the University.