RES FACIL CONST: GROWTH, DEVELOPMENT & GENETICS: PREHAIR, LENS FORMATION

资源设施建设：增长、发展

• 批准号: 6794431
• 负责人: RICHARD J SUNDBERG
• 金额: $ 38.13万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794431
• 关键词: biomedical facility; building /facility design /renovation; developmental genetics; growth /development; histogenesis; imaging /visualization /scanning; lens; molecular biology; stem cells; university

DESCRIPTION (provided by applicant): The long-term objective of this application is to enhance the biomedical research capabilities in molecular and cellular biology in the Department of Biology and the UVA. Specific aims are to renovate on the ground floor of Gilmer Hall to provide the following: 1) three modern molecular and cellular biology research laboratories; 2) support areas and conference rooms for use of these and other cell and molecular biology laboratories; and 3) research and support space to consolidate at one site the currently dispersed personnel and equipment of an existing research laboratory. Morphogenesis was identified in an internal and external review of the Department of Biology as the major initiative for emphasis. The Biology Department is strong in developmental genetics, developmental biology, and imaging technology, especially in light of complementing strengths in the School of Medicine nearby, and morphogenesis is an area of exciting progress with the advent of the genome projects, development of new imaging and biophysical methods, and new possibilities for medical applications in stem cell research. To enhance existing strengths and take advantage of these new developments, the Department of Biology must strengthen its cell biological approaches to morphogenesis, specifically in such areas as the cytoskeleton, molecular motors, cell adhesion, cell polarity, transport and localization of RNA and proteins, cell adhesion, and cell migration. The proposed renovations will include new laboratory space for two new research faculties in these areas and provide support areas for these and existing laboratories throughout Gilmer Hall, thus enhancing biomedical research programs in Biology and elsewhere at the University.

描述（由申请人提供）：本申请的长期目标是提高生物系和UVA在分子和细胞生物学方面的生物医学研究能力。具体目标是在吉尔默大厅的底层进行翻新，以提供以下内容：1）三个现代化的分子和细胞生物学研究实验室; 2）支持这些和其他细胞和分子生物学实验室使用的区域和会议室;以及3）研究和支持空间，将现有研究实验室目前分散的人员和设备集中在一个地点。在生物系的内部和外部审查中，形态发生被确定为重点的主要举措。生物系在发育遗传学，发育生物学和成像技术方面实力雄厚，特别是在附近医学院的互补优势方面，形态发生是随着基因组项目的出现，新成像和生物物理方法的发展以及干细胞研究中医学应用的新可能性而取得令人兴奋的进展的领域。为了加强现有的优势，并利用这些新的发展，生物学系必须加强其细胞生物学方法形态发生，特别是在细胞骨架，分子马达，细胞粘附，细胞极性，RNA和蛋白质的运输和定位，细胞粘附和细胞迁移等领域。拟议的改造将包括在这些领域的两个新的研究院系的新的实验室空间，并为这些和整个吉尔默大厅现有的实验室提供支持领域，从而加强生物学和其他地方的生物医学研究计划在大学。