RES FACIL CONST: DEGENERATE AMINERGIC NEURON

描述（由申请人提供）：本申请的长期目标是提高生物学系和弗吉尼亚大学在分子和细胞生物学方面的生物医学研究能力。具体目的是在Gilmer Hall一楼进行改造，提供以下功能：1)三个现代分子和细胞生物学研究实验室；2)支持使用这些和其他细胞和分子生物学实验室的区域和会议室；3)研究和支持空间，将现有研究实验室目前分散的人员和设备整合在一个地点。形态发生在生物系的内部和外部审查中被确定为强调的主要倡议。生物系在发育遗传学、发育生物学和成像技术方面实力雄厚，特别是考虑到附近医学院的互补优势，随着基因组计划的出现，新的成像和生物物理方法的发展，以及干细胞研究中医学应用的新可能性，形态发生是一个令人兴奋的进展领域。为了增强现有优势并利用这些新发展，生物系必须加强其细胞生物学方法，以形态发生，特别是在细胞骨架，分子马达，细胞粘附，细胞极性，RNA和蛋白质的运输和定位，细胞粘附和细胞迁移等领域。拟议的改造将包括为这些地区的两个新研究学院提供新的实验室空间，并为这些实验室和整个吉尔默大厅的现有实验室提供支持区域，从而加强生物医学研究项目和大学其他地方。

DESCRIPTION (provided by applicant): The long-term objective of this application is to enhance the biomedical research capabilities in molecular and cellular biology in the Department of Biology and the UVA. Specific aims are to renovate on the ground floor of Gilmer Hall to provide the following: 1) three modern molecular and cellular biology research laboratories; 2) support areas and conference rooms for use of these and other cell and molecular biology laboratories; and 3) research and support space to consolidate at one site the currently dispersed personnel and equipment of an existing research laboratory. Morphogenesis was identified in an internal and external review of the Department of Biology as the major initiative for emphasis. The Biology Department is strong in developmental genetics, developmental biology, and imaging technology, especially in light of complementing strengths in the School of Medicine nearby, and morphogenesis is an area of exciting progress with the advent of the genome projects, development of new imaging and biophysical methods, and new possibilities for medical applications in stem cell research. To enhance existing strengths and take advantage of these new developments, the Department of Biology must strengthen its cell biological approaches to morphogenesis, specifically in such areas as the cytoskeleton, molecular motors, cell adhesion, cell polarity, transport and localization of RNA and proteins, cell adhesion, and cell migration. The proposed renovations will include new laboratory space for two new research faculties in these areas and provide support areas for these and existing laboratories throughout Gilmer Hall, thus enhancing biomedical research programs in Biology and elsewhere at the University.