GENETIC BASIS OF SYNDROME X ON THE ISLAND OF KOSRAE

描述（改编自研究者摘要）：本申请提出了一项 一系列的遗传和临床研究，以阐明遗传基础， 高血压、肥胖症、糖尿病和血脂异常。这些疾病往往 当他们彼此相遇时，他们彼此相遇。 X综合征这些疾病的基础，这是主要原因， 发病率和死亡率，在很大程度上是未知的。的发生率 肥胖、高血压、糖尿病和血脂异常在太平洋上增加 科斯雷岛。在1994年完成的研究中， 从2364名20岁以上的科斯雷人中提取了DNA， 几乎所有的成年人。在本申请中，研究人员 我建议通过在人类中应用现代方法来完成这项遗传研究， 遗传学来绘制导致X综合征成分的基因。此外，本发明还提供了一种方法， 将对整个人群进行随访临床研究， 岛16岁以上预计这将增加1000个新的 参与者

DESCRIPTION (Adapted from investigator's abstract): This application proposes a series of genetic and clinical studies to elucidate the genetic basis of hypertension, obesity, diabetes and dyslipidemia. These diseases are often associated with one another and when they occur together they are referred to as Syndrome X. The basis for these disorders, which are principal causes of morbidity and mortality worldwide, is largely unknown. The incidence of obesity, hypertension, diabetes and dyslipidemia is increased on the Pacific Island of Kosrae. In studies completed in 1994, a medical evaluation was conducted and DNA was isolated from each of 2364 Kosraeans over the age 20, nearly the entire adult population. In this application, the investigators propose to complete this genetic study by applying modern methods in human genetics to map the genes that cause the components of Syndrome X. In addition, a follow-up clinical study will be performed on the entire population of the island over 16 years old. It is expected that this will add 1000 new participants.