GENETIC BASIS OF SYNDROME X ON THE ISLAND OF KOSRAE

科斯雷岛 X 综合征的遗传基础

• 批准号: 6381602
• 负责人: JEFFREY M FRIEDMAN
• 金额: $ 82.8万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381602
• 关键词: Pacific Islander; blood chemistry; clinical research; diabetes mellitus; electrocardiography; gene environment interaction; gene expression; gene interaction; genetic disorder; genetic mapping; genetic susceptibility; genotype; human genetic material tag; human population study; human subject; hypertension; linkage disequilibriums; lipid disorder; longitudinal human study; obesity; pathologic process; phenotype; polymerase chain reaction; statistics /biometry

DESCRIPTION (Adapted from investigator's abstract): This application proposes a series of genetic and clinical studies to elucidate the genetic basis of hypertension, obesity, diabetes and dyslipidemia. These diseases are often associated with one another and when they occur together they are referred to as Syndrome X. The basis for these disorders, which are principal causes of morbidity and mortality worldwide, is largely unknown. The incidence of obesity, hypertension, diabetes and dyslipidemia is increased on the Pacific Island of Kosrae. In studies completed in 1994, a medical evaluation was conducted and DNA was isolated from each of 2364 Kosraeans over the age 20, nearly the entire adult population. In this application, the investigators propose to complete this genetic study by applying modern methods in human genetics to map the genes that cause the components of Syndrome X. In addition, a follow-up clinical study will be performed on the entire population of the island over 16 years old. It is expected that this will add 1000 new participants.

描述(改编自调查人员摘要)：本申请提出了一种 一系列遗传学和临床研究，以阐明遗传病的基础 高血压、肥胖症、糖尿病和血脂异常。这些疾病通常是 它们彼此关联，当它们一起出现时，它们被称为 作为综合症X。这些疾病的基础，这是 全世界的发病率和死亡率在很大程度上是未知的。的发病率。 太平洋地区肥胖、高血压、糖尿病和血脂异常增加 科斯雷岛。在1994年完成的研究中，一项医学评估是 从2364名20岁以上的科索沃人中分离出DNA， 几乎整个成年人口。在本申请中，调查人员 建议通过在人类身上应用现代方法来完成这项遗传学研究 遗传学绘制导致X综合征的基因图谱。此外， 一项后续的临床研究将在整个人群中进行 岛上有16岁以上的儿童。预计这将增加1000个新的 参与者。