DIIRON CHEMISTRY IN MACROCYCLIC DICARBOXYLATE LIGANDS

蛋白质通过其多肽“主干”加强结构的完整性，主干作为控制活性部位残基的访问和方向的基质。使用简单的羧酸盐配体在模型络合物中复制这些特征通常是困难的，因为它们的动力学不稳定性和与金属离子的多种结合模式。这项研究计划描述了一系列具有两个克隆酸部分的环番化合物，它们以内切方式定位，并以双齿桥联的方式结合两个金属离子。有人提出，这样一系列的环番二羧酸盐配体将提供一个口袋，将立体地保护双金属核心，并通过大环效应提供更高的动力学稳定性。这些配体的作用是为各种生物相关的金属蛋白提供双金属模型。

Proteins enforce structural integrity via their polypeptide "backbone", which serves as a matrix controlling the access to and the orientation of residues in the active site. Duplication of these features in model complexes using simple carboxylate ligands is often difficult due to their kinetic lability and large variety of binding modes to metal ions. This research proposal describes a series of cyclophanes with two craboxylate moieties positioned in an endo-fashion and oriented to bind two metal ions in a bidentate bridging mode. It is proposed that such a series of cyclophane dicarboxylate ligands would provide a pocket that would sterically protect the dimetallic core and offer increased kinetic stability via the macrocyclic effect. The role of these ligands is to afford dimetallic models for a variety of biologically relevant metalloproteins.