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DEVELOPMENT OF NETWORK ACTIVITY IN THALAMOCORTICAL CIRCUITS

DEVELOPMENT OF NETWORK ACTIVITY IN THALAMOCORTICAL CIRCUITS
丘脑皮质回路网络活动的发展
批准号:
6354126
负责人:
David McCormick
金额:
$10.17万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-03-01 至 2003-02-28

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项目成果

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中文摘要
翻译
丘脑皮质网络的发育与活动无关
英文摘要
Development of thalamocortical networks proceeds in an activity-independent phase during which the basic axonal connections are formed, followed by an activity-dependent phase during which these axonal connections are refined to achieve the high anatomical and synaptic specificity characteristic of the adult brain. During this activity-dependent phase, athe activation of the NMDA subtype of glutamate inotropic receptor is believed to facilitate synaptic plasticity. In the mammalian visual system, retinogeniculate fibers segregate into eye specific layers prior to visual experience, and this segregation is disrupted by block of spontaneous activity. These results indicate that non-visually driven activity may play a key role in the determination of appropriate anatomical connections in the visual system. In addition, during this period of formation and definition of synaptic circuits, spontaneous activity in the forebrain, as represented by the electroencephalogram (EEG), is becoming more and more characteristic of the adult animal. This development of the EEG includes the appearance and maturation of both normal (e.g. spindle waves) and abnormal (e.g. absence seizures) synchronized oscillations in thalamocortical systems. Recently we have demonstrated that the ferret LGNd, maintained as a slice in vitro, exhibits spontaneous synchronized oscillations characteristic of the developing and adult brain in situ and that this in vitro preparation is useful for the cellular analysis of development of synaptic and network properties in thalamocortical systems. Therefore, in the present study, we will investigate the cellular mechanisms of development of non-visually related synchronized activity int he ferret LGNd, the development of GABAergic inhibition within the LGNd, the contribution of NMDA receptors to thalamocortical monosynaptic EPSPs, and the regulation of activation of NMDA receptors by intracortical GABAergic inhibitory interneurons. These studies will provide for a cellular level understanding for the development, generation, and propagation of synchronized network activity in thalamocortical systems. This increased understanding of synchronized oscillations and synaptic function will lead to a better understanding of the development of synaptic connections and function in the mammalian forebrain and possible to therapeutic options for the prevention of generalized seizures.
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Brain States and Flexible Behavior
  • 批准号:
    10700739
  • 项目类别:
  • 资助金额:
    $74.87万
  • 财政年份:
    2020
  • 负责人:
    David McCormick
  • 依托单位:
LFA-9 (mPGES-1/5-LOX Inhibitor): Preclinical Studies to Support a Clinical Trial,
  • 批准号:
    10399397
  • 项目类别:
  • 资助金额:
    $84.42万
  • 财政年份:
    2018
  • 负责人:
    David McCormick
  • 依托单位:
LFA-9 (mPGES-1/5-LOX Inhibitor): Preclinical Studies to Support a Clinical Trial,
  • 批准号:
    10794912
  • 项目类别:
  • 资助金额:
    $41.87万
  • 财政年份:
    2018
  • 负责人:
    David McCormick
  • 依托单位:
IGF::OT::IGF NExT Preclinical Toxicology & Pharmacology of Drugs Developed for Cancer Patients, TO#3, Exploratory Studies of CCR4 CART Cells
  • 批准号:
    10361380
  • 项目类别:
  • 资助金额:
    $23.86万
  • 财政年份:
    2017
  • 负责人:
    David McCormick
  • 依托单位:
海外基金